Microbiota and Endometriosis: is there a relathionship? A review of the literature

Rocío González García
In: Enfermería Cuidándote · 2025 · pp. 142 · doi:10.51326/ec.8.1519194 · W4412151280
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Abstract

Introduction: Endometriosis is a disease characterized by the growth of endometrial tissue outside the uterus, causing pelvic pain, infertility, and inflammation. The microbiota, especially the intestinal and vaginal microbiota, plays a crucial role in hormonal and immune regulation, and may contribute to the pathogenesis of endometriosis. Objectives: To analyze the relationship between the intestinal microbiota and the female reproductive system and endometriosis, and to investigate the changes in the vaginal, uterine, and intestinal microbiota present in women with this disease. Methodology: An exhaustive search was carried out in scientific databases using DeCS/MeSH terms. The selected articles were in Spanish or English and published between 2014 and 2024. After evaluating their scientific quality, 30 relevant articles were analyzed. Results: The review shows significant alterations in the vaginal, uterine, and intestinal microbiota of women with endometriosis, highlighting dysbiosis characterized by the decrease of beneficial bacteria and the increase of pathogens. These alterations are associated with chronic inflammation, alterations in estrogen metabolism, and disease progression. Discussion: Microbiota analysis could be useful as a noninvasive diagnostic tool. The use of Lactobacillus, vaginal probiotics, and specific antibiotics is proposed as treatment. Conclusions: Microbiota plays a relevant role in the development of endometriosis. It is necessary to continue research and promote public health support to improve the diagnosis and treatment of the disease, which would contribute to improving the quality of life of affected women.

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endometriosisinfertility

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