Additional file 1 of Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis

Su, Wenliang, Cui, Huan, Wu, Danning, Yu, Jiawen, Ma, Lulu, Zhang, Xiuhua, Huang, Yuguang, Ma, Chao
2021 · doi:10.6084/m9.figshare.14173922.v1 · W6902156344
other OA: green CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

Endometriosis significantly upregulated cytoplasmic HMGB1 in dorsal root ganglia neurons, and increased HMGB1 staining intensity in the spinal dorsal horn.

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Abstract

Additional file 1: Fig. S1 Analysis of HMGB1 expression in DRG and SDH. A. Immunofluorescence staining showed EM significantly upregulated the cytoplasmic HMGB1 in the DRG. N=3, one-way ANOVA, *P < 0.05 versus sham. B. Percentages of cytoplasmic HMGB1-positive DRG neurons from EM 14d group in neurons with marker of CGRP, IB4 and TRPV1. C. Analysis of staining intensity for HMGB1 indicated the upregulation of HMGB1 by EM in the SDH. 9 slices from 3 rats in each group, *P < 0.05, Student's t-test, EM 14d versus Sham.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

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