Comparaison de deux stratégies thérapeutiques dans les endométrioses sévères, chez des femmes jeunes consultant pour stérilité ou douleurs. II. En cas dˈinfertilité, intérêt des stimulations ovariennes avec inséminations intra-utérines après la chirurgie

Rim Amrani, R el Amrani, el Amrani R, J Henry-Suchet, Henry-Suchet J, J Henry‐Suchet, Cornier E, E Cornier, Sarjdine K, K Sarjdine, J.-M. Mayenga, J M Mayenga, Mayenga JM, T Loysel, Loysel T, J. Belaïsch-Allart, J. Belaisch-Allart, Belaisch-Allart J
Gynecologie, obstetrique & fertilite · 2001 · vol. 29(3) , pp. 192–199 · doi:10.1016/s1297-9589(00)00074-6 · PMID:11300044 · W1979871840
article OA: closed CC0 ⤵ 2 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-28 ⓘ

This paper compared two therapeutic strategies for severe endometriosis in young women with infertility or pain, focusing on the benefit of ovarian stimulation with intrauterine insemination after surgery in cases of infertility.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Aim of the studyDefine the best medico surgical strategy in infertile women with stage III-IV endometriosis.Material and methodsTwo groups, A (N26) and B (N 37), treated for infertility associated or not with pelvic pain, due to stage AFS III or IV endometriosis, were compared. They had similar surgical procedure: operative laparoscopy including resection of endometriotic lesions, more particularly endometriomas and rectovaginal septum nodules. Associated medical strategy was different: group A, operative laparoscopy without preoperative treatment and in 40% a second laparoscopy taking place after 2-3 months of LHRH analogues; no post operative treatment; group B, operative laparoscopy taking place after ovarian blockage with 3-6 weeks of Diane (Androcur + ethinyl estradiol), then 2-3 months of analogue postoperative treatment immediately followed by ovarian stimulation (OS) + intrauterine insemination (IUI) in women more than 30 years old with operative tubes (N 22), no treatment for six months in similar cases less than 30 (N 5), and IVF in women with damaged tubes (N 5) or after OS + IUI failure (N 4). One patient refused two patients with high FSH level had oocyte donation.ResultsTwo years evolutive pregnancy rate was significantly higher (p < 0.01) in group B (59%) versus group A (23%) and was higher after OS + IUI (68%) than after IVF (55%) or without any treatment in women < 30 (43%). The difference is equally significant by age (p < 0.05), for endometriomas (p < 0.01) and for recurrences (p < 0.01).ConclusionSimilar results obtained for pelvic pain (see chapter I) suggest that both strategies are similarly successful in treating endometriosis. These results confirm the interest of an ART after surgery for stage III-IV endometriosis and show that OS + IUI, a less costly than IVF technique, can be used successfully in selected cases with operative tubes.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Infertility, Female Infertility, Female Ovulation Induction Adult Androgen Antagonists Androgen Antagonists Androgen Antagonists Cyproterone Acetate Cyproterone Acetate Cyproterone Acetate Drug Combinations Endometriosis Ethinyl Estradiol Ethinyl Estradiol Ethinyl Estradiol Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (16)

Cited by (2)

Source provenance

europepmc
last seen: 2026-08-02T06:10:09.037253+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:24.901228+00:00
License: CC0 · commercial use OK