Müllerian-inhibiting substance in follicular fluid and serum: a comparison of patients with tubal factor infertility, polycystic ovary syndrome, and endometriosis

Mary E. Fallat, M E Fallat, Y Siow, Siow Y, Yong Siow, Maureen Marra, Marra M, M Marra, Cook C, C Cook, Christine Cook, A Carrillo, Alberto Carrillo, Carrillo A
Fertility and Sterility · 1997 · vol. 67(5) , pp. 962–965 · doi:10.1016/s0015-0282(97)81417-3 · PMID:9130910 · W2110680211
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This study compared Müllerian-inhibiting substance levels in follicular fluid and serum between women with tubal factor infertility, polycystic ovary syndrome, and endometriosis.

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Abstract

ObjectiveTo determine Müllerian inhibiting substance (MIS) levels in follicular fluid (FF) and sera of IVF patients.DesignProspective study.SettingFertility center.Patient(s)Sixty-six patients: 20 with tubal factor infertility, 17 with polycystic ovary syndrome (PCOS), and 29 with endometriosis.Intervention(s)All patients underwent ovarian stimulation with hMG and/or FSH, as well as oocyte retrieval for IVF.Main outcome measure(s)Follicular fluid and serum MIS levels and oocyte fertilization rates.Result(s)Levels of MIS in FF and sera of PCOS patients were significantly higher than those in tubal factor patients: 7.01 +/- 1.52 versus 1.65 +/- 0.23 ng/mL (mean +/- SE) and 2.97 +/- 0.52 versus 0.92 +/- 0.19 ng/mL, respectively. In endometriosis patients, follicular fluid and serum MIS levels were not significantly different from those in tubal factor patients. In PCOS patients, the percentage of immature oocytes retrieved (17.9% +/- 5.0%) was significantly higher compared with tubal factor (1.5% +/- 1.0%) and endometriosis (9.2% +/- 2.3%) patients. The percentage of oocytes fertilize was significantly lower in PCOS patients (30.2% +/- 5.3%) compared with tubal factor (62.2% +/- 5.5%) and endometriosis (37.5% +/- 5.7%) patients.Conclusion(s)Women with PCOS had higher serum and follicular fluid MIS levels, a higher percentage of immature oocytes, and lower fertilization rates than women with endometriosis or pelvic adhesions.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Fallopian Tube Diseases Follicular Fluid Glycoproteins Growth Inhibitors Infertility, Female Polycystic Ovary Syndrome Testicular Hormones Adult Anti-Mullerian Hormone Endometriosis Endometriosis Endometriosis Fallopian Tube Diseases Fallopian Tube Diseases Fallopian Tube Diseases Female Fertilization in Vitro Follicle Stimulating Hormone Follicle Stimulating Hormone

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