ENDOMETRIOSIS

Arif Malik, Iram Qamar, Uzma Jamil, Gulshan Parveen, Sulayman Waquar, Hassan Shafique
In: The Professional Medical Journal · 2018 · vol. 25(11) · doi:10.29309/tpmj/18.4593 · W4241035377
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found significantly higher levels of MDA, IL-8, MMP-2, TNF-α, and estradiol, and decreased SOD, CAT, and GSH, along with lower testosterone and 17β-HSD-II in endometriosis patients compared to controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This comparative cross-sectional study from Jinnah Hospital Lahore assessed 100 women with endometriosis and 100 controls for biomarkers related to oxidative stress, inflammation, and matrix remodeling, including melondialdehyde (MDA), antioxidant enzymes (SOD, CAT, GSH), interleukins, matrix metalloproteinases (notably MMP-2), vitamin D, PGE-2/COX-2, estradiol, and related hormones. Women with endometriosis had significantly higher MDA, IL-8, MMP-2, TNF-α, and estradiol, alongside significantly lower SOD, CAT, and GSH, and lower testosterone and 17β-HSD-II. The authors conclude that oxidative stress and vitamin D are implicated in disease progression, mediated through increased PGE-2 and COX-2. A key limitation is that the study is cross-sectional, so it cannot establish causality or temporal relationships between these biomarkers and endometriosis. This paper is centrally about endometriosis — it evaluates oxidative stress, vitamin D, and inflammatory/matrix markers in women with endometriosis in relation to infertility.

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Abstract

Objectives: To evaluate the role of endometriosis leading to infertility in workingfemales. Data Source: Data was collected and screened from Jinnah Hospital Lahore. Designand Study: Comparative cross sectional study was performed. Setting: Study was carriedout in the Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore.Period: Present study was carried out over a period of two years from 14-11-2014 to 15-11-2016.Material and Methods: Hundred (n=100) patients of endometriosis and hundred (n=100)controls were added in the current study. Subjects were analyzed for the levels of MDA, SOD,CAT, GSH, ILs, MMPs, Vit-D, PGE-2, Estradiol, COX-2 and various hormones with the help oftheir respective spectrophotometric and kit protocols. Results: Levels of MDA, IL-8, MMP-2,TNF-á and Estradiol were significantly higherin patients of endometriosis (2.99±0.16 nmol/ml,19.65±3.26 pg/ml, 563.23±48.2 ng/ml, 31.29±4.25 pg/ml and 47.16±4.28 pg/ml) vs. healthyfemales (0.88±0.089 nmol/ml, 10.26±1.99pg/ml, 299.35±54.4 ng/ml, 21.26±3.26pg/ml and22.28±4.16pg/ml), whereas levels of SOD, CAT and GSH remained decreased significantly inpatients infected by endometriosis (652.23±42.6, 1226.06±108.4 and 6.28±0.42 respectively).Levels of testosterone and 17â-HSD-II were also significantly decreased females withendometriosis (15.23±1.99 ng/dL and 0.12±0.04 pg/ml respectively). Conclusion: The currentstudy indicates role of oxidative stress and vitamin-D in females with endometriosis. Lowerlevels of vitamin-D and increased oxidative stress is responsible for release of induced factorsi.e., PGE-2 and COX-2. These factors play their role in activation of signaling cascades involvedin progression of endometriosis. Hence, vitamin-D and antioxidant supplementation may havea beneficial role in the disease management.
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Objectives

To evaluate the role of endometriosis leading to infertility in working females. Data Source: Data was collected and screened from Jinnah Hospital Lahore. Design and Study: Comparative cross sectional study was performed. Setting: Study was carried out in the Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore. Period: Present study was carried out over a period of two years from 14-11-2014 to 15-11-2016.

Material and methods

Hundred (n=100) patients of endometriosis and hundred (n=100) controls were added in the current study. Subjects were analyzed for the levels of MDA, SOD, CAT, GSH, ILs, MMPs, Vit-D, PGE-2, Estradiol, COX-2 and various hormones with the help of their respective spectrophotometric and kit protocols. Results: Levels of MDA, IL-8, MMP-2, TNF-á and Estradiol were significantly higherin patients of endometriosis (2.99±0.16 nmol/ml, 19.65±3.26 pg/ml, 563.23±48.2 ng/ml, 31.29±4.25 pg/ml and 47.16±4.28 pg/ml) vs. healthy females (0.88±0.089 nmol/ml, 10.26±1.99pg/ml, 299.35±54.4 ng/ml, 21.26±3.26pg/ml and 22.28±4.16pg/ml), whereas levels of SOD, CAT and GSH remained decreased significantly in patients infected by endometriosis (652.23±42.6, 1226.06±108.4 and 6.28±0.42 respectively). Levels of testosterone and 17â-HSD-II were also significantly decreased females with endometriosis (15.23±1.99 ng/dL and 0.12±0.04 pg/ml respectively). Conclusion: The current study indicates role of oxidative stress and vitamin-D in females with endometriosis. Lower levels of vitamin-D and increased oxidative stress is responsible for release of induced factors i.e., PGE-2 and COX-2. These factors play their role in activation of signaling cascades involved in progression of endometriosis. Hence, vitamin-D and antioxidant supplementation may have a beneficial role in the disease management.

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endometriosisinfertility

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