{"paper_id":"d527c4b8-7534-4fdc-98cb-69a43be0f938","body_text":"ENDOMETRIOSIS\nINSINUATIONS OF UPSTREAM PROPHETIC VARIABLES AND THEIR INTERPLAY TO DEVELOP ENDOMETRIOSIS IN YOUNG FEMALES\nDOI:\nhttps://doi.org/10.29309/TPMJ/18.4593Keywords:\nMelondialdehyde (MDA), Vitamin-D, Matrix Metalloproteinases (MMPs), Interleukins (ILs), TestosteroneAbstract\nObjectives: To evaluate the role of endometriosis leading to infertility in working\nfemales. Data Source: Data was collected and screened from Jinnah Hospital Lahore. Design\nand Study: Comparative cross sectional study was performed. Setting: Study was carried\nout in the Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore.\nPeriod: Present study was carried out over a period of two years from 14-11-2014 to 15-11-2016.\nMaterial and Methods: Hundred (n=100) patients of endometriosis and hundred (n=100)\ncontrols were added in the current study. Subjects were analyzed for the levels of MDA, SOD,\nCAT, GSH, ILs, MMPs, Vit-D, PGE-2, Estradiol, COX-2 and various hormones with the help of\ntheir respective spectrophotometric and kit protocols. Results: Levels of MDA, IL-8, MMP-2,\nTNF-á and Estradiol were significantly higherin patients of endometriosis (2.99±0.16 nmol/ml,\n19.65±3.26 pg/ml, 563.23±48.2 ng/ml, 31.29±4.25 pg/ml and 47.16±4.28 pg/ml) vs. healthy\nfemales (0.88±0.089 nmol/ml, 10.26±1.99pg/ml, 299.35±54.4 ng/ml, 21.26±3.26pg/ml and\n22.28±4.16pg/ml), whereas levels of SOD, CAT and GSH remained decreased significantly in\npatients infected by endometriosis (652.23±42.6, 1226.06±108.4 and 6.28±0.42 respectively).\nLevels of testosterone and 17â-HSD-II were also significantly decreased females with\nendometriosis (15.23±1.99 ng/dL and 0.12±0.04 pg/ml respectively). Conclusion: The current\nstudy indicates role of oxidative stress and vitamin-D in females with endometriosis. Lower\nlevels of vitamin-D and increased oxidative stress is responsible for release of induced factors\ni.e., PGE-2 and COX-2. These factors play their role in activation of signaling cascades involved\nin progression of endometriosis. Hence, vitamin-D and antioxidant supplementation may have\na beneficial role in the disease management.","source_license":"CC0","license_restricted":false}