Cyclical endometrial repair and regeneration

Lois A. Salamonsen, Jennifer C. Hutchison, Caroline E. Gargett
Development (Cambridge, England) · 2021 · vol. 148(17) · doi:10.1242/dev.199577 · PMID:34486650 · W3198361313
Review OA: bronze CC0 ⤵ 21 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This review examines the cyclical repair and regeneration of the human endometrium, focusing on stem/progenitor cell contributions, the stem cell niche, extracellular vesicles, and the utility of endometrial epithelial organoids.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes. This Review examines what is known of endometrial repair and regeneration following menstruation and parturition, including comparisons with wound repair and the influence of menstrual fluid components. We also discuss the contribution of endometrial stem/progenitor cells to endometrial regeneration, including the importance of the stem cell niche and stem cell-derived extracellular vesicles. Finally, we comment on the value of endometrial epithelial organoids to extend our understanding of endometrial development and regeneration, as well as therapeutic applications.

My notes (saved in your browser only)

MeSH descriptors

Endometrium Regeneration Cell Proliferation Endometrium Endometrium Extracellular Vesicles Extracellular Vesicles Female Humans In Vitro Techniques Menstruation Parturition Stem Cells Stem Cells Stem Cells

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (24)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:32:22.069507+00:00
License: CC0 · commercial use OK