The effectiveness of danazol therapy in postmenopausal women affected by endometrial hyperplasia.
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Danazol therapy at 400 mg/day for 3 months effectively regressed endometrial hyperplasia in 95.9% of postmenopausal women, with only two cases showing persistent hyperplasia.
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Abstract
Forty eight patients in postmenopause affected by histologically confirmed endometrial hyperplasia (34 with simplex and 14 with complex forms) were administered Danazol therapy, 400 mg/day for 3 consecutive months. At the end of treatment, regression of the endometrial hyperplasia was histologically ascertained in 46 patients (95.9%) with disappearance of the metrorrhagia. Endometrial atrophy was obtained in 75% of the cases, while secretive (14.7%) or proliferative (6.2%) aspects resulted in the others. Only 2 patients (4.1%) showed persistence of the hyperplastic endometrium. On the basis of this experience, treatment with Danazol appears to be effective and safe with only scarce and transient side effects. This therapy is therefore proposed as a valid alternative to progestogen therapy in cases of postmenopausal endometrial hyperplasia.
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Cited by (6)
- Postmenopausal endometriosis: a challenging condition beyond menopause 2024
- Therapeutic Options for Management of Endometrial Hyperplasia: An Update 2015
- Treatment of Endometrial Hyperplasia with a Danazol-Releasing Intrauterine Device: A Prospective Study 2004
- Preventive effects of danazol on endometrial carcinogenesis in mice 2000
- Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology 1998
- Postmenopausal endometrial hyperplasia: role of danazol therapy 1994
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