The Association Between Daily Intake of Dietary Supplements and Self-Reported Endometriosis: A NHANES-Based Study

Kaiquan Li, Wenchao Zhang
Reproductive sciences (Thousand Oaks, Calif.) · 2024 · vol. 31(7) , pp. 1936–1947 · doi:10.1007/s43032-024-01464-4 · PMID:38379072 · W4391951284
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Higher dietary fiber and protein intake were associated with reduced endometriosis risk, particularly in normal-weight women.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This NHANES-based cross-sectional study examined whether daily dietary supplement intake is associated with self-reported endometriosis initiation/progression using 3,950 U.S. participants from 1999–2006, with infertility assessed via a question about year-long attempts to become pregnant and associations tested using weighted multivariate logistic regression plus BMI-stratified subgroup analyses. Higher dietary fiber content and density were associated with lower endometriosis risk (e.g., Q4 vs Q1 OR ~0.56 for content and ~0.55 for density), and protein content and density also showed negative associations in the overall analysis. These associations appeared more pronounced in normal-weight women, while they were not evident in overweight/obese participants, and protein-related effects were not significant across subpopulations. The paper emphasizes that findings require future research to validate and establish a causal link; relevance to endometriosis: the study directly targets endometriosis risk with dietary supplement nutrient measures in a NHANES cohort, making it centrally applicable to endometriosis research. This paper is centrally about endometriosis — it analyzes how daily supplement nutrient intake is associated with self-reported endometriosis risk in NHANES.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements

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License: CC0 · commercial use OK