Method for Electrochemical Detection of Brain Derived Neurotrophic Factor (BDNF) in Plasma

M. Bockaj, Bockaj M, B Fung, Fung B, Barnabas Fung, M Tsoulis, Michael Tsoulis, Lauren Foster, Leyla Soleymani
Analytical chemistry · 2018 · vol. 90(14) , pp. 8561–8566 · doi:10.1021/acs.analchem.8b01642 · PMID:29932639 · W2809276704
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This study developed a point-of-care electrochemical biosensor (EndoChip) using a gold film electrode for rapid BDNF detection in plasma, showing strong correlation with ELISA results for potential endometriosis diagnosis.

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Abstract

Currently, a blood test for the diagnosis of endometriosis, a common estrogen-dependent gynecological disease, does not exist. Recent studies suggest that circulating concentrations of brain-derived neurotrophic factor (BDNF) have potential for the diagnosis of endometriosis. However, at present, BDNF can only be measured by ELISA, which requires a clinic visit, a routine blood sample, and laboratory testing. Therefore, we developed a point-of-care device (EndoChip) for use with small blood volumes that can be collected through a finger prick. Specifically, the presented device is a polymer-based chip with a nanoporous, wrinkled gold film acting as the electrode/sensing layer, allowing for the electrochemical detection of BDNF in plasma. Increasing concentrations of BDNF (0.1–2.0 ng/mL) induced significant differences in redox current. The biosensor produces a signal readout in a matter of seconds, and is ideal for realizing multiplexing. Blood samples were collected from women (n = 20) with chronic pelvic pain undergoing a diagnostic laparoscopy. Plasma BDNF concentrations measured by commercial ELISA were positively correlated (r2 = 0.8033; p < 0.001) with results from the EndoChip. Our results demonstrate a quick and reliable method for point-of-care quantification of circulating concentrations of BDNF and a promising diagnostic tool for endometriosis.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Biosensing Techniques Brain-Derived Neurotrophic Factor Endometriosis Point-of-Care Systems Adolescent Adult Biosensing Techniques Brain-Derived Neurotrophic Factor Electrochemical Techniques Electrochemical Techniques Electrodes Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Equipment Design Female Gold Gold Humans Lab-On-A-Chip Devices

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License: CC0 · commercial use OK