Leiomyomatosis peritonealis disseminata, endometriosis, and multicystic mesothelioma: an unusual association

Zotalis G, G Zotalis, George Zotalis, Ritu Nayar, R Nayar, Nayar R, Hicks DG, D G Hicks, David G. Hicks
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 1998 · vol. 17(2) , pp. 178–182 · doi:10.1097/00004347-199804000-00015 · PMID:9553817 · W2077607415
Case report OA: closed CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This report describes a 32-year-old woman with simultaneous leiomyomatosis peritonealis disseminata, endometriosis, and multicystic mesothelioma discovered during infertility evaluation.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-21 · read from full text ⓘ

This case report describes a 32-year-old woman presenting with primary infertility who was initially diagnosed with stage III ovarian cancer based on laparoscopic findings of a diffuse peritoneal process and bilateral ovarian lesions. Surgical intervention revealed an unusual pathological triad consisting of leiomyomatosis peritonealis disseminata, endometriosis, and multicystic mesothelioma, marking the first known simultaneous occurrence of these three distinct conditions. The authors note that while endometriosis is frequently associated with either leiomyomatosis peritonealis disseminata or multicystic mesothelioma individually, this specific combination has not been previously documented in medical literature. This paper is centrally about endometriosis — specifically its rare co-occurrence with leiomyomatosis peritonealis disseminata and multicystic mesothelioma in a single patient.

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Abstract

A 32-year-old, previously healthy woman with a diffuse, complex tumoral process is described. While she was being evaluated for primary infertility, a laparoscopic procedure revealed a disseminated peritoneal process associated with bilateral ovarian lesions. A clinical diagnosis of stage III ovarian cancer was made and total hysterectomy, bilateral salpingo-oophorectomy, and omentectomy were performed. Pathologic studies showed an admixture of leiomyomatosis peritonealis disseminata (LPD) endometriosis, and an extensive multicystic mesothelial proliferation. Although endometriosis is known to occur in conjunction with either LPD or multicystic mesothelioma, to our knowledge this is the first report of all three lesions occurring simultaneously.
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Leiomyomatosis Peritonealis Disseminata, Endometriosis, and Multicystic Mesothelioma An Unusual Association - George Zotalis - Ritu Nayar - David G. Hicks Summary A 32-year-old, previously healthy woman with a diffuse, complex tumoral process is described. While she was being evaluated for primary infertility, a laparoscopic procedure revealed a disseminated peritoneal process associated with bilateral ovarian lesions. A clinical diagnosis of stage III ovarian cancer was made and total hysterectomy, bilateral salpingo-oophorectomy, and omentectomy were performed. Pathologic studies showed an admixture of leiomyomatosis peritonealis disseminata (LPD) endometriosis, and an extensive multicystic mesothelial proliferation. Although endometriosis is known to occur in conjunction with either LPD or multicystic mesothelioma, to our knowledge this is the first report of all three lesions occurring simultaneously.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Leiomyomatosis Mesothelioma, Cystic Peritoneal Neoplasms Adult Adult Diagnosis, Differential Diagnosis, Differential Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Leiomyomatosis Leiomyomatosis Leiomyomatosis Leiomyomatosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (11)

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License: CC0 · commercial use OK