Correlation between laparoscopic and histopathologic diagnosis of endometriosis

Sikolia Wanyonyi, Sikolia Z Wanyonyi, Evan Sequeira, E Sequeira, Sequeira E, Samuel G Mukono, Mukono SG
International Journal of Gynecology & Obstetrics · 2011 · vol. 115(3) , pp. 273–276 · doi:10.1016/j.ijgo.2011.07.022 · PMID:21944490 · W2007116712
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This retrospective review found that laparoscopic visualization of endometriosis does not always correlate with histopathologic diagnosis, with several other lesions mimicking endometriosis microscopically.

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This retrospective study reviewed medical charts from Aga Khan University Hospital (Nairobi) for 2001–2010, selecting patients who had endometriosis diagnosed by laparoscopy with documented lesion site, size, morphology, and number of lesions, and who had biopsy specimens submitted for histopathology. Among 152 eligible cases (239 biopsy specimens), histopathologic confirmation of endometriosis occurred in 63.8%, and laparoscopic findings did not consistently match microscopic diagnoses; the authors report that histopathologic correlation was associated with Asian race, multiparity, and chronic pelvic pain. They found that neither lesion site nor disease stage influenced histopathologic diagnosis and note that other lesions can mimic endometriosis on histopathology. This paper is centrally about endometriosis — it evaluates the correlation between laparoscopic visualization and histopathologic confirmation of endometriosis.

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Abstract

OBJECTIVE: To review the histopathologic diagnosis of biopsies taken following visualization of endometriosis at laparoscopy and to correlate visual with microscopic diagnoses. METHODS: A retrospective review was undertaken of medical charts with a diagnosis of endometriosis at Aga Khan University Hospital, Nairobi, Kenya, between January 2001 and October 2010. Eligibility included visual diagnosis of endometriosis at laparoscopy, with a clear record of site, size, morphology, and number of lesions. The histopathologic diagnosis of the biopsies sampled was sought. Correlation was undertaken using κ statistics for diagnostic variability. RESULTS: Of the 204 relevant records, 152 (74.5%) met the eligibility criteria; from these cases, 239 specimens were submitted for histology. The most common symptom was chronic pelvic pain (108 [71.1%]). Most biopsies were obtained from the ovary and posterior cul-de-sac. Histopathologic diagnosis was confirmed in (152 [63.8%]) specimens and correlated with Asian race, multiparity, and chronic pelvic pain. Neither the site of the lesion nor the stage of disease influenced the histopathologic diagnosis. CONCLUSION: Laparoscopic visualization of endometriosis does not always correlate with histopathologic diagnosis; several other lesions may mimic endometriosis on histopathologic examination.
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Abstract

Objective: To review the histopathologic diagnosis of biopsies taken following visualization of endometriosis at laparoscopy and to correlate visual with microscopic diagnoses.

Methods

A retrospective review was undertaken of medical charts with a diagnosis of endometriosis at Aga Khan University Hospital, Nairobi, Kenya, between January 2001 and October 2010. Eligibility included visual diagnosis of endometriosis at laparoscopy, with a clear record of site, size, morphology, and number of lesions. The histopathologic diagnosis of the biopsies sampled was sought. Correlation was undertaken using κ statistics for diagnostic variability.

Results

Of the 204 relevant records, 152 (74.5%) met the eligibility criteria; from these cases, 239 specimens were submitted for histology. The most common symptom was chronic pelvic pain (108 [71.1%]). Most biopsies were obtained from the ovary and posterior cul-de-sac. Histopathologic diagnosis was confirmed in (152 [63.8%]) specimens and correlated with Asian race, multiparity, and chronic pelvic pain. Neither the site of the lesion nor the stage of disease influenced the histopathologic diagnosis.

Conclusion

Laparoscopic visualization of endometriosis does not always correlate with histopathologic diagnosis; several other lesions may mimic endometriosis on histopathologic examination. Publication (Name of Journal) International journal of gynaecology and obstetrics Recommended Citation Wanyonyi, S., Sequeira, E., Mukono, S. (2011). Correlation between laparoscopic and histopathologic diagnosis of endometriosis. International journal of gynaecology and obstetrics, 115, 272-275. Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_obstet_gynaecol/10 Creative Commons License This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Laparoscopy Adolescent Adult Biopsy Endometriosis Endometriosis Female Humans Kenya Laparoscopy Middle Aged Ovary Ovary Retrospective Studies Young Adult

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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