Neurologic Manifestations of Endometriosis: A Review of Preclinical and Clinical Evidence

Jaya Prakash, Rochelle Akerman, Hilary Haber
In: Current Obstetrics and Gynecology Reports · 2025 · vol. 14(1) · doi:10.1007/s13669-025-00433-1 · W4413168984
review OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This review synthesizes preclinical and clinical findings on neurologic manifestations of endometriosis, including nerve infiltration, neuroinflammation, and brain changes, highlighting a complex interplay with the nervous system.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This review synthesizes preclinical and clinical evidence on neurologic manifestations of endometriosis, focusing on mechanisms involving peripheral and central pain sensitization, neuroimmune dysregulation, autonomic dysfunction, nerve infiltration, and structural/functional brain changes, with discussion of rare central and peripheral nerve cases. It highlights that ectopic endometrial lesions can link to comorbid neurologic and psychiatric conditions, including frequent migraine, cognitive impairment, and mood disorders, drawing on findings from both animal models and human studies. The paper’s explicit caveat is that it is a narrative synthesis rather than an original dataset, with no new human or animal experiments conducted or analyzed by the authors. This paper is centrally about endometriosis — specifically reviewing neurologic manifestations and the preclinical and clinical evidence for peripheral and central nervous system involvement.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK