{"paper_id":"ce330ca2-1650-44cf-acaf-a05b28e06c48","body_text":"Abstract\nPurpose\nEndometriosis, a chronic inflammatory condition traditionally associated with pelvic pain and infertility, is increasingly recognized as a systemic disorder with significant neurologic implications. This review synthesizes current clinical and preclinical findings that elucidate the neurological manifestations of endometriosis, including nerve infiltration, neuroinflammation, autonomic dysfunction, and structural and functional brain changes.\nRecent Findings\nEmerging evidence highlights a complex interplay between ectopic endometrial lesions and the nervous system, involving both peripheral and central mechanisms of pain sensitization, neuroimmune dysregulation, and comorbid neurologic and psychiatric conditions. The discussion also encompasses rare but critical cases of central and peripheral nerve involvement, as well as the frequent co-occurrence of migraines, cognitive impairments, and mood disorders. By integrating insights from neuroscience, immunology, and gynecology, this paper underscores the need for multidisciplinary diagnostic and therapeutic strategies.\nSummary\nRecognizing endometriosis as a disorder with neurologic dimensions is essential for improving patient outcomes and guiding future research toward more effective, individualized interventions.\nSimilar content being viewed by others\nData Availability\nNo datasets were generated or analysed during the current study.\nReferences\nHorne AW, Missmer SA. Pathophysiology, diagnosis, and management of endometriosis. BMJ. 2022;379.\nHoward FM. Endometriosis and mechanisms of pelvic pain. J Minim Invasive Gynecol. 2009;16(5):540–50.\nWoolf CJ. 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J Clin Med. 2024;13(16):4676.\nFunding\nThis study has received no financial support.\nAuthor information\nAuthors and Affiliations\nContributions\nR.A. performed literature review. J.P. wrote the main manuscript text. H.H. performed conceptualization, revisions, and supervision of manuscript preparation. All authors reviewed the manuscript.\nCorresponding author\nEthics declarations\nHuman and Animal Rights\nThis article does not contain any studies with human or animal subjects performed by any of the authors.\nCompeting Interests\nThe authors declare no competing interests.\nAdditional information\nPublisher’s Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nPrakash, J., Akerman, R. & Haber, H. Neurologic Manifestations of Endometriosis: A Review of Preclinical and Clinical Evidence. Curr Obstet Gynecol Rep 14, 27 (2025). https://doi.org/10.1007/s13669-025-00433-1\nAccepted:\nPublished:\nVersion of record:\nDOI: https://doi.org/10.1007/s13669-025-00433-1","source_license":"CC0","license_restricted":false}