Utility of Ultrasound in the Evaluation of Adolescents Suspected of Endometriosis

In: Endometriosis in Adolescents · 2020 · pp. 333–355 · doi:10.1007/978-3-030-52984-0_17 · W3102002553
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Transvaginal sonography is useful in adolescent patients for detecting pelvic endometriosis, including retroperitoneal lesions and adenomyosis, offering more comprehensive evaluation than diagnostic laparoscopy.

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Abstract

Transvaginal sonography (TVS) has been proposed as the first-line imaging technique in evaluating patients with pain and suspicion for endometriosis because it allows extensive exploration of the pelvis. In young patients, TVS showed great advantages over TAUS in the ability to place a high-frequency transducer next to the region of interest and to the possible endometriotic lesions in the pelvis. A transrectal approach with TVS probe may be considered in adolescents with an intact hymen. Small “typical” endometrioma is a unilocular cyst with homogeneous low-level echogenicity (ground glass echogenicity) of the cyst fluid that could be seen in teenagers. In adolescent patients with chronic pelvic pain, it is also important to look for sonographic signs of adhesions and TVS “soft markers” (i.e., site-specific tenderness, reduced ovarian mobility). The 2D real-time dynamic TVS examination of adhesions and pouch of Douglas (POD) obliteration, using the sliding sign technique, seems to be useful in the identification of adhesion and small posterior deep endometriotic lesions. Utilizing TVS, an accurate assessment of the vagina, particularly the areas of the posterior and lateral vaginal fornices, the retrocervical area with torus uterinum, the uterosacral ligaments, and the rectovaginal septum, should be performed. The slightly filled bladder permits to better evaluate the structure of the walls and the presence of endometriotic nodules, which appears as hypoechoic linear or spherical lesions bulging toward the lumen, involving the serosa, muscularis, or (sub)mucosa of the bladder. Deep endometriotic nodes of the rectum appear as hypoechoic lesions, linear or nodular retroperitoneal thickening with irregular borders, penetrating into the intestinal wall distorting its normal structure. It seems very important to evaluate in adolescent patients small lesion below the peritoneum between the vagina and rectum that could not be seen by the purely diagnostic laparoscopy which is often be performed in these patients when imaging is negative. 2D TVS typical myometrial features and 3D evaluation of the junctional zone seem very important to diagnose adenomyosis. Increased JZ thickness or small adenomyotic cysts of the inner or outer myometrium can be detected in adolescent patients with dysmenorrhea or excessive menstrual bleeding. In adolescent patients, an accurate TVS can provide a lot of information, and being able to detect retroperitoneal endometriotic lesions and adenomyosis is probably better than a purely diagnostic laparoscopy that evaluates only superficial lesion. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

Dei M, Morelli C. La dismenorrea nell’adolescente tra fisiologia e patologia. Riv Sessuol. 2012;36:11–5. Goldstein DP, De Cholnoky C, Emansi SJ. Adolescent endometriosis. J Adolesc Health Care. 1980;1:37–41. Yang YP, Wang Y, Jie Yang JY, Wang S, Lang JH. Adolescent endometriosis in China: a retrospective analysis of 63 cases. J Pediatr Adolesc Gynecol. 2012;25:295–9. Chapron C, Lafay-Pillet MC, Monceau E, et al. Questioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosis. Fertil Steril. 2011;95:877–88. Dun EC, Kho KA, Morozov VV, Kearney S, Zurawin JL, Nezhat CH. Endometriosis in adolescents. JSLS. 2015;19(2) https://doi.org/10.4293/JSLS.2015.00019. Nezhat C, Santolaya J, Nezhat FR. Comparison of transvaginal sonography and bimanual pelvic examination in patients with laparoscopically confirmed endometriosis. J Am Assoc Gynecol Laparosc. 1994;1(2):127–30. Zannoni L, Giorgi M, Spagnolo E, Montanari G, Villa G, Seracchioli R. Dysmenorrhea, absentee- ism from school, and symptoms suspicious for endometriosis in adolescents. J Pediatr Adolesc Gynecol. 2014;27:258–65. Laufer MR. Helping “adult gynecologist” diagnose and treat adolescent endometriosis: reflections on my 20 years of personal experience. J Pediatr Adolesc Gynecol. 2011;24:S13–7. Shah DK, Missmer SA. Scientific investigation of endometriosis among adolescents. J Pediatr Adolesc Gynecol. 2011;24:S18–9. Okaro E, Condous G, Khalid A, Timmerman D, Ameye L, Huffel SV, et al. The use of ultrasound-based ‘soft markers’ for the prediction of pelvic pathology in women with chronic pelvic pain–can we reduce the need for laparoscopy? BJOG. 2006;113(3):251–6. Reid S, Lu C, Casikar I, Reid G, Abbott J, Cario G, Chou D, Kowalski D, Cooper M, Condous G. Prediction of pouch of Douglas obliteration in women with suspected endometriosis using a new real-time dynamic transvaginal ultrasound technique: the sliding sign. Ultrasound Obstet Gynecol. 2013;41:685–91. Guerriero S, Ajossa S, Mais V, Risalvato A, Lai MP, Melis GB. The diagnosis of endometriomas using colour Doppler energy imaging. Hum Reprod. 1998;13:1691–5. Van Holsbeke C, Van Calster B, Guerriero S, Savelli L, Paladini D, Lissoni AA, et al. Endometriomas: their ultrasound characteristics. Ultrasound Obstet Gynecol. 2010;35:730–40. Exacoustos C, Zupi E, Carusotti C, Rinaldo D, Marconi D, Lanzi G, Arduini D. Staging of pelvic endometriosis: role of sonographic appearance in determining extension of disease and modulating surgical approach. J Am Assoc Gynecol Laparosc. 2003;3:378–82. Holland TK, Yazbek J, Cutner A, Saridogan E, Hoo WL, Jurkovic D. The value of transvaginal ultrasound in assessing the severity of pelvic endometriosis. Ultrasound Obstet Gynecol. 2010;36:241–8. Menakaya U, Infante F, Lu C, Phua C, Model A, Messyne F, Brainwood M, Reid S, Condous G. Interpreting the real-time dynamic ‘sliding sign’ and predicting POD obliteration: an inter-, intra-observer, diagnostic accuracy and learning curve study. Ultrasound Obstet Gynecol. 2016;48:113–20. Hudelist G, Oberwinkler KH, Singer CF, Tuttlies F, Rauter G, Ritter O, et al. Combination of transvaginal sonography and clinical examination for preoperative diagnosis of pelvic endometriosis. Hum Reprod. 2009;24:1018–24. Hudelist G, Fritzer N, Staettner S, Tammaa A, Tinelli A, Sparic R, et al. Uterine sliding sign: a simple sonographic predictor for presence of deep infiltrating endometriosis of the rectum. Ultrasound Obstet Gynecol. 2013;41:692–5. Gerges B, Lu C, Reid S, Chou D, Chang T, Condous G. Sonographic evaluation of immobility of normal and endometriotic ovary in detection of deep endometriosis. Ultrasound Obstet Gynecol. 2017;49:793–8. Guerriero S, Ajossa S, Garau N, Alcazar JL, Mais V, Melis GB. Diagnosis of pelvic adhesions in patients with endometrioma: the role of transvaginal ultrasonography. Fertil Steril. 2010;94:742–6. Timor-Tritsch IE, Lerner JP, Monteagudo A, Murphy KE, Heller DS. Transvaginal sonographic markers of tubal inflammatory disease. Ultrasound Obstet Gynecol. 1998;12:56–66. Fedele L, Bianchi S, Raffaelli R, Portuese A. Pre-operative assessment of bladder endometriosis. Hum Reprod. 1997;12:2519–22. Savelli L, Manuzzi L, Pollastri P, Mabrouk M, Seracchioli R, Venturoli S. Diagnostic accuracy and potential limitations of transvaginal sonography for bladder endometriosis. Ultrasound Obstet Gynecol. 2009;34:595–600. Guerriero S, Ajossa S, Gerada M, D'Aquila M, Piras B, Melis GB. “Tenderness-guided” transvaginal ultrasonography: a new method for the detection of deep endometriosis in patients with chronic pelvic pain. Fertil Steril. 2007;88:1293–7. Exacoustos C, Malzoni M, Di Giovanni A, Lazzeri L, Tosti C, Petraglia F, Zupi E. Ultrasound mapping system for the surgical management of deep infiltrating endometriosis. Fertil Steril. 2014;102:143–50. Exacoustos C, Manganaro L, Zupi E. Imaging for the evaluation of endometriosis and adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2014;28:655–81. Guerriero S, Condous G, van den Bosch T, Valentin L, Leone FP, Van Schoubroeck D, Exacoustos C, Installé AJ, Martins WP, Abrao MS, et al. Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group. Ultrasound Obstet Gynecol. 2016;48:318–32. Pateman K, Mavrelos D, Hoo WL, Holland T, Naftalin J, Jurkovic D. Visualization of ureters on standard gynecological transvaginal scan: a feasibility study. Ultrasound Obstet Gynecol. 2013;41:696–701. Guerriero S, Ajossa S, Gerada M, Virgilio B, Angioni S, Melis GB. Diagnostic value of transvaginal ‘tenderness-guided’ ultrasonography for the prediction of location of deep endometriosis. Hum Reprod. 2008;23:2452–7. Belghiti J, Thomassin-Naggara I, Zacharopoulou C, Zilberman S, Jarboui L, Bazot M, Ballester M, Darai E. Contribution of computed tomography enema and magnetic resonance imaging to diagnose multifocal and multicentric bowel lesions in patients with colorectal endometriosis. J Minim Invasive Gynecol. 2015;22:776–84. Leyendecker G, Wildt L, Mall G. The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. Arch Gynecol Obstet. 2009;280:529–38. Dueholm M. Transvaginal ultrasound for diagnosis of adenomyosis: a review. Best Pract Res Clin Obstet Gynaecol. 2006;20:569–82. Reinhold C, Tafazoli F, Mehio A, Wang L, Atri M, Siegelman ES, et al. Uterine adenomyosis: endovaginal US and MR imaging features with histopathologic correlation. Radiographics. 1999;19 Spec No:S147–60. Dueholm M, Lundorf E, Hansen ES, Sorensen JS, Ledertoug S, Olesen F. Magnetic resonance imaging and transvaginal ultrasonography for the diagnosis of adenomyosis. Fertil Steril. 2001;76:588–94. Bazot M, Cortez A, Darai E, Rouger J, Chopier J, Antoine JM, et al. Ultrasonography compared with magnetic resonance imaging for the diagnosis of adenomyosis: correlation with histopathology. Hum Reprod. 2001;16:2427–33. Dueholm M, Lundorf E. Transvaginal ultrasound or MRI for diagnosis of adenomyosis. Curr Opin Obstet Gynecol. 2007;19:505–12. Champaneria R, Abedin P, Daniels J, Balogun M, Khan KS. Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: systematic review comparing test accuracy. Acta Obstet Gynecol Scand. 2010;89:1374–84. Gordts S, Campo R, Brosens I. Hysteroscopic diagnosis and excision of myometrial cystic adenomyosis. Gynecol Surg. 2014;11:273–8. Bromley B, Shipp TD, Benacerraf B. Adenomyosis: sonographic findings and diagnostic accuracy. J Ultrasound Med. 2000;19:529–34. Kepkep K, Tuncay YA, Goynumer G, Tutal E. Transvaginal sonography in the diagnosis of adenomyosis: which findings are most accurate? Ultrasound Obstet Gynecol. 2007;30:341–5. Van den Bosch T, Dueholm M, Leone FP, Valentin L, Rasmussen CK, Votino A, Van Schoubroeck D, Landolfo C, Installé AJ, Guerriero S, Exacoustos C, et al. Terms and definitions for describing myometrial pathology using ultrasonography. Ultrasound Obstet Gynecol. 2015;46:284–98. Di Donato N, Bertoldo V, Montanari G, Zannoni L, Caprara G, Seracchioli R. A simple sonographic sign associated to the presence of adenomyosis. Ultrasound Obstet Gynecol. 2015;46:126–7. Van den Bosch T, de Bruijn AM, de Leeuw RA, Dueholm M, Exacoustos C, Valentin L, Bourne T, Timmerman D, Huirne JAF. A sonographic classification and reporting system for diagnosing adenomyosis. Ultrasound Obstet Gynecol. 2019;53:576–82. https://doi.org/10.1002/uog.19096. Lazzeri L, Morosetti G, Centini G, Monti G, Zupi E, Piccione E, Exacoustos C. A sonographic classification of adenomyosis: interobserver reproducibility in the evaluation of type and degree of the myometrial involvement. Fertil Steril. 2018;110:1154–1161e3. Fedele L, Bianchi S, Dorta M, Zanotti F, Brioschi D, Carinelli S. Transvaginal ultrasonography in the differential diagnosis of adenomyoma versus leiomyoma. Am J Obstet Gynecol. 1992;167:603–6. Brosens I, Gordts S, Habiba M, Benagiano G. Uterine cystic adenomyosis: a disease of younger women. J Pediatr Adolesc Gynecol. 2015;28:420–6. Naftalin J, Hoo W, Pateman K, Mavrelos D, Holland T, Jurkovic D. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum Reprod. 2012;27:3432–9. Pinzauti S, Lazzeri L, Tosti C, Centini G, Orlandini C, Luisi S, Zupi E, Exacoustos C, Petraglia F. Transvaginal sonographic features of diffuse adenomyosis in 18-30-year-old nulligravid women without endometriosis: association with symptoms. Ultrasound Obstet Gynecol. 2015;46:730–6. Di Donato N, Montanari G, Benfenati A, Leonardi D, Bertoldo V, Monti G, et al. Prevalence of adenomyosis in women undergoing surgery for endometriosis. Eur J Obstet Gynecol Reprod Biol. 2014;181:289–93. Lazzeri L, Di GA, Exacoustos C, Tosti C, Pinzauti S, Malzoni M, et al. Preoperative and postoperative clinical and transvaginal ultrasound findings of adenomyosis in patients with deep infiltrating endometriosis. Reprod Sci. 2014;21:1027–33. Naftalin J, Jurkovic D. The endometrial-myometrial junction: a fresh look at a busy crossing. Ultrasound Obstet Gynecol. 2009;34:1–11. Exacoustos C, Brienza L, Di Giovanni A, Szabolcs B, Romanini ME, Zupi E, Arduini D. Adenomyosis: three-dimensional sonographic findings of the junctional zone and correlation with histology. Ultrasound Obstet Gynecol. 2011;37:471–47. Conflict of Interest All the authors report no conflict of interest. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2020 Springer Nature Switzerland AG About this chapter Cite this chapter Exacoustos, C., Martire, F.G., Lazzeri, L., Zupi, E. (2020). Utility of Ultrasound in the Evaluation of Adolescents Suspected of Endometriosis. In: Nezhat, C.H. (eds) Endometriosis in Adolescents. Springer, Cham. https://doi.org/10.1007/978-3-030-52984-0_17 Download citation DOI: https://doi.org/10.1007/978-3-030-52984-0_17 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-030-52983-3 Online ISBN: 978-3-030-52984-0 eBook Packages: MedicineMedicine (R0)

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