Dienogest as preoperative treatment of submucous myomas for hysteroscopic surgery: a prospective, randomized study

Antonio Simone Laganà, Valentina Giacobbe, Onofrio Triolo, Roberta Granese, Helena Ban Frangež, Eda Vrtačnik Bokal, Eda Vrtačnik-Bokal, Chiara Ietto, Vittorio Italo Palmara, Vittorio Palmara
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2016 · vol. 32(5) , pp. 408–411 · doi:10.3109/09513590.2015.1128409 · PMID:26743136 · W2232251710
RCT OA: closed CC0 ⤵ 5 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This randomized study found that dienogest, compared to danazol, more effectively atrophies the endometrium, reduces operative time, infusion volume, and bleeding severity, and causes fewer side effects in patients undergoing hysteroscopic surgery for submucous myomas.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The aim of this single-center, prospective, randomized, parallel-group study was to compare Dienogest and Danazol as endometrial preparation in patients who have to undergo hysteroscopic surgery for submucous myomas. We enrolled 80 consecutive eligible patients, in reproductive age, affected by submucous myomas. Pre- and posttreatment characterization of endometrium was performed by hysteroscopic visual observation and histologic confirmation. The enrolled patients were randomly assigned to two groups: 40 were treated with 2 mg of Dienogest/die, 40 with 100 mg of Danazol/die, both orally for 5 weeks, starting on day 1 of menstruation. Posttreatment comparison of endometrial patterns showed a significant more marked effect of Dienogest, respect to Danazol, in atrophying endometrium ("normotrophic non-responders" versus "hypotrophic"-"atrophic", p = 0.028). Intraoperative data showed no significant difference between the two groups for cervical dilatation time (p = 0.326), while in the Dienogest group, we found a significant reduction of operative time (p = 0.001), infusion volume (p = 0.001), and severity of bleeding (p = 0.042). Moreover, Dienogest caused less side effects (p = 0.008). According to our data analysis, Dienogest, respect to Danazol, is more effective for the preparation of the endometrium in patients who have to undergo hysteroscopic surgery for submucous myomas, and causes less side effects.

My notes (saved in your browser only)

Condition tags

die_deep_infiltrating

MeSH descriptors

Danazol Hormone Antagonists Hysteroscopy Leiomyoma Nandrolone Uterine Neoplasms Adult Danazol Female Hormone Antagonists Humans Hysteroscopy Leiomyoma Leiomyoma Nandrolone Nandrolone Preoperative Care Preoperative Period Prospective Studies Treatment Outcome

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (4)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:17:08.544769+00:00
License: CC0 · commercial use OK