Invasive capacity of heterotopic endometrium
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⤵ 13 in-corpus citations
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Heterotopic endometrial stromal cells secreted significantly more urokinase-type plasminogen activator (uPA) and epithelial cells overexpressed its receptor (uPAR), correlating with increased invasive potential.
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Abstract
Because endometriotic tissue is capable of implantation and invasion, it resembles neoplastic tissue. This biologic behavior is likely regulated by cell adhesion molecules and enzymes that degrade the extracellular matrix. A potential factor in the local regulation of tumor cell invasion is the urokinase-type plasminogen activator (uPA) system. This study was undertaken to characterize the expression of both uPA and its receptor (uPAR) in the eutopic and heterotopic endometrial cells from women with adenomyosis by testing both types of epithelial cells for invasive ability. By Western blot and zymographic analyses, stromal cells from heterotopic endometrium secreted 12 times more uPA antigen and uPA-dependent caseinolytic activity than did the eutopic stromal cells. The heterotopic epithelial cells overexpressed uPAR by a factor of four times the expression seen in the eutopic epithelial cells. When respective stromal cells were cocultured, the heterotopic epithelial cells exhibited significantly higher invasive ability through Matrigel than did the eutopic epithelial cells. uPAR overexpression in the epithelial cells and high secretion of uPA from the stromal cells may contribute to the invasive phenotype of heterotopic endometrium.
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References (8)
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Cited by (13)
- Biomaterial Tools for Modeling Endometriosis 2026
- Identification of differentially expressed genes and signaling pathways involved in endometriosis by integrated bioinformatics analysis 2019
- Morphological and immunohistochemical characterization of spontaneous endometriosis in rhesus macaques (Macaca mulatta) 2017
- Upregulation of CFTR in patients with endometriosis and its involvement in NFκB-uPAR dependent cell migration 2017
- Peritoneal fluid reduces angiogenesis-related microRNA expression in cell cultures of endometrial and endometriotic tissues from women with endometriosis 2013
- Evolving spectrum: the pathogenesis of endometriosis 2010
- Reviews: in vitro models to study the pathogenesis of endometriosis 2009
- Altered expression of claudin-3 and claudin-4 in ectopic endometrium of women with endometriosis 2008
- Nuclear factor-kappab (NF-kappaB): an unsuspected major culprit in the pathogenesis of endometriosis that is still at large? 2006
- DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection 2005
- mRNA analysis of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis using a real-time quantitative RT-PCR assay 2004
- Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis 2003
- Effects of hormones on uPA, PAI-1 and suPAR from cultured endometrial and ovarian endometriotic stromal cells 2002
Source provenance
- europepmc
- last seen: 2026-10-08T06:18:23.926119+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T20:59:38.477535+00:00
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