Traitement chirurgical de l’endométriose digestive : entre l’approche limitée et radicale

In: Côlon & Rectum · 2016 · vol. 10(3) , pp. 174–180 · doi:10.1007/s11725-016-0662-2 · W2484783050
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This paper reviews surgical approaches for digestive endometriosis, contrasting radical resection for complete implant removal with conservative resection to avoid functional sequelae, noting that neither strategy is definitively superior.

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The paper reviews digestive (bowel) endometriosis and contrasts two surgical philosophies for rectal and rectosigmoid disease: a radical approach aiming for complete micro- and macroscopical resection of implants, versus a more conservative approach aiming for selective excision to limit functional sequelae. It describes that radical surgery typically requires segmental colorectal resection and carries concern for functional morbidity, while conservative surgery often avoids larger resections but requires postoperative hormonal therapy to reduce recurrence risk. The authors explicitly state that there is no study available to recommend one strategy over the other, with only the ongoing randomized ENDORE trial expected to compare functional digestive outcomes after radical versus conservative surgery. Relevance to endometriosis: the paper is centrally about endometriosis of the digestive tract, specifically comparing limited versus radical surgical treatment strategies for rectal endometriosis.

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Abstract

L’endométriose digestive est définie par une infiltration endométriosique de la musculeuse pariétale du tube digestif et affecte 8 % à 30 % des patientes porteuses d’endométriose. Les localisations rectales et de la charnière rectosigmoïdienne sont les plus fréquentes et représentent jusqu’à 90 % de l’ensemble de ces lésions. Deux approches chirugicales existent dans la prise en charge de ces patientes que sont l’approche radicale et conservatrice. L’approche radicale a pour objectif la résection micro- et macroscopiquement complète des implants digestifs d’endométriose afin de réduire au minimum le risque de récidives digestives; elle consiste à réaliser de manière systématique des résections colorectales segmentaires et expose à un risque de séquelles fonctionnelles. L’approche conservatrice vise à réaliser chaque fois que possible des exérèses sélectives afin d’éviter les séquelles fonctionnelles, mais nécessite un traitement hormonal postopératoire pour éviter les récidives. Il n’existe à ce jour, aucune étude permettant de recommander une stratégie plutôt que l’autre. Les résultats de l’essai contrôlé randomisé ENDORE pourront prochainement apporter des informations sur les résultats fonctionnels digestifs chez les patientes opérées d’une endométriose rectale par résection colorectale ou chirurgie conservatrice.
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Résumé L’endométriose digestive est définie par une infiltration endométriosique de la musculeuse pariétale du tube digestif et affecte 8 % à 30 % des patientes porteuses d’endométriose. Les localisations rectales et de la charnière rectosigmoïdienne sont les plus fréquentes et représentent jusqu’à 90 % de l’ensemble de ces lésions. Deux approches chirugicales existent dans la prise en charge de ces patientes que sont l’approche radicale et conservatrice. L’approche radicale a pour objectif la résection micro- et macroscopiquement complète des implants digestifs d’endométriose afin de réduire au minimum le risque de récidives digestives; elle consiste à réaliser de manière systématique des résections colorectales segmentaires et expose à un risque de séquelles fonctionnelles. L’approche conservatrice vise à réaliser chaque fois que possible des exérèses sélectives afin d’éviter les séquelles fonctionnelles, mais nécessite un traitement hormonal postopératoire pour éviter les récidives. Il n’existe à ce jour, aucune étude permettant de recommander une stratégie plutôt que l’autre. Les résultats de l’essai contrôlé randomisé ENDORE pourront prochainement apporter des informations sur les résultats fonctionnels digestifs chez les patientes opérées d’une endométriose rectale par résection colorectale ou chirurgie conservatrice. Abstract Digestive endometriosis is defined by infiltration of the muscular layer of bowel wall with endometriotic tissue. This condition affects 8 to 30% of the patients suffering from endometriosis. Rectal wall and low sigmoid are commonly affected (90% of digestive locations). Surgical approaches can be radical or conservative. Radical approach aims to resect the whole digestive implants of endometriotic tissue to offer the patient a maximum healing rate. In that case, colorectal resection is mandatory. Morbidity is fair but severe complications have been reported particularly on the functional results. Conservative approach aims to limit the resection and the risk of functional sequelae. There is no randomised trial to compare both surgical approaches. One ongoing trial “ENDORE” will answer this question by comparing radical resection to conservative approach. Références Bailey HR, Ott MT, Hartendorp P (1994) Aggressive surgical management for advanced colorectal endometriosis. Dis Colon Rectum 37:747–53 Campagnacci R, Perretta S, Guerrieri M, et al (2005) Laparoscopic colorectal resection for endometriosis. Surg Endosc 19:662–4 Vercellini P, Crosignani PG, Abbiati A, et al (2009) The effect of surgery for symptomatic endometriosis: the other side of the story. Hum Reprod Update 15:177–188 Ferrero S, Camerini G, Ragni N, et al (2010) Letrozole and norethisterone acetate in colorectal endometriosis. Eur J Obstet Gynecol Reprod Biol 150:199–202 Nisolle-Pochet M, Casanas-Roux F, Donnez J (1988) Histologic study of ovarian endometriosis after hormonal therapy. Fertil Steril 49:423–6 Fedele L, Bianchi S, Zanconato G, et al (2000) Gonadotropinreleasing hormone agonist treatment for endometriosis of the rectovaginal septum. Am J Obstet Gynecol 183:1462–7 Meuleman C, Tomassetti C, D’Hoore A, et al (2011) Surgical treatment of deeply infiltrating endometriosis with colorectal involvement. Hum Reprod Update 17:311–26 Darai E, Thomassin I, Barranger E, et al (2005) Feasibility and clinical outcome of laparoscopic colorectal resection for endometriosis. 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J Minim Invasive Gynecol 23:512–25 Meuleman C, Tomassetti C, Wolthuis A, et al (2014) Clinical outcome after radical excision of moderate-severe endometriosis with or without bowel resection and reanastomosis: a prospective cohort study. Ann Surg 259:522–31 Emmertsen KJ, Laurberg S, Rectal Cancer Function Study G (2013) Impact of bowel dysfunction on quality of life after sphincter-preserving resection for rectal cancer. Br J Surg 100:1377–87 Remorgida V, Ragni N, Ferrero S, et al (2005) How complete is full thickness disc resection of bowel endometriotic lesions? A prospective surgical and histological study. Hum Reprod 20:2317–20 Possover M, Diebolder H, Plaul K, Schneider A (2000) Laparascopically assisted vaginal resection of rectovaginal endometriosis. Obstet Gynecol 96:304–7 Landi S, Ceccaroni M, Perutelli A, et al (2006) Laparoscopic nerve-sparing complete excision of deep endometriosis: is it feasible? 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Fertil Steril 99:1695–704 Moawad NS, Guido R, Ramanathan R, et al (2011) Comparison of laparoscopic anterior discoid resection and laparoscopic low anterior resection of deep infiltrating rectosigmoid endometriosis. JSLS 15:331–8 Nirgianakis K, McKinnon B, Imboden S, et al (2014) Laparoscopic management of bowel endometriosis: resection margins as a predictor of recurrence. Acta Obstet Gynecol Scand 93:1262–7 Roman H, Hennetier C, Darwish B (2016) Bowel occult microscopic endometriosis in resection margins in deep colorectal endometriosis specimens has no impact on short-term postoperative outcomes. Fertil Steril 105:423–9 Seracchioli R, Mabrouk M, Frasca C, et al (2010) Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial. Fertil Steril 93:52–6 Author information Authors and Affiliations Corresponding author About this article Cite this article Bridoux, V., Roman, H. & Tuech, J.J. Traitement chirurgical de l’endométriose digestive : entre l’approche limitée et radicale. Colon Rectum 10, 174–180 (2016). https://doi.org/10.1007/s11725-016-0662-2 Published: Issue date: DOI: https://doi.org/10.1007/s11725-016-0662-2 Mots clés - Endométriose digestive - Endométriose colorectale - Chirurgie - Résection segmentaire - Résection en pastille - Shaving rectal

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