Differential expression of progesterone receptor isoforms related to PGR +331g/a polymorphism in endometriosis: A case-control study

Sepideh Mousazadeh, Mousazadeh S, Azadeh Ghaheri, Shahhoseini M, Maryam Shahhoseini, Reza Aflatoonian, Aflatoonian R, Parvaneh Afsharian, Afsharian P
International journal of reproductive biomedicine · 2019 · vol. 17(3) , pp. 185–194 · doi:10.18502/ijrm.v17i3.4517 · PMID:31435600 · PMC6661139 · W2953321225
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This study found that endometriosis patients with the GA genotype of the PGR +331G/A polymorphism exhibited significantly higher PR-B mRNA expression compared to those with the GG genotype.

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This case-control study examined differential expression of progesterone receptor (PGR) isoforms in relation to the PGR +331G/A polymorphism in women with endometriosis, using a genetic and expression-focused comparison between affected and control participants. The key finding was that PGR isoform expression differed according to the PGR +331G/A genotype, linking a specific genetic variant to altered progesterone receptor isoform profiles in endometriosis tissue/cells assessed by the study. The paper’s main limitation is its case-control design, which cannot establish causality between the polymorphism, receptor isoform expression, and endometriosis development. This paper is centrally about endometriosis—specifically, how PGR isoform expression relates to the PGR +331G/A polymorphism in endometriosis.

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Abstract

BACKGROUND: Endometriosis are defined as a progesterone-resistance disease. Two progesterone receptor (PR) isoforms, namely PR-A and PR-B, mediate the special effects of progesterone. One of the most effective polymorphism in the promoter region of PGR is the +331G/A. OBJECTIVE: The differential expression level of PR isoforms due to +331G/A polymorphism may be able to influence the function of progesterone and reduce the susceptibility of endometriosis. MATERIALS AND METHODS: This analytic, case-control study was carried out at Royan Institute, Tehran, Iran. Whole-blood samples were collected from 98 infertile women undergoing laparoscopy for endometriosis and 102 healthy fertile women. After DNA extraction, genotype frequencies were determined by polymerase chain reaction-restriction fragment length polymorphism. Then, RNA was extracted from the selected eutopic tissue samples of endometriosis patients. Analysis of PR-A and PR-B mRNA expressions were performed using Real-time polymerase chain reaction. RESULTS: The frequency distribution of GG, GA genotypes in +331G/A polymorphism was 98.04%, 1.96% in the patients and 97.96%, 2.04% in the control groups, respectively (p = 0.968). Although our data did not show any significant association with +331G/A in the patient and control groups, we were able to demonstrate significantly higher expression level of PR-B and no significant lower expression level of PR-A isoforms in patients by favoring GA to GG genotypes (p = 0.017, p = 0.731, respectively). CONCLUSION: Our findings show that patients with GA genotypes had a higher expression level of PR-B compared to patients with GG genotypes.
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Publication International Journal of Reproductive BioMedicine (IJRM) Record type Journal article Published 29 May 2019 Authors Sepideh Mousazadeh | Azadeh Ghaheri | Maryam Shahhoseini | Reza Aflatoonian | Parvaneh Afsharian The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ijrm.v17i3.4517', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'International Journal of Reproductive BioMedicine (IJRM)', 'primary-resource': 'https://knepublishing.com/index.php/ijrm/article/view/4517', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'http://journals.ssu.ac.ir/ijrmnew/article-1-1451-en.html', 'tld': 'ssu.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://knepublishing.com/index.php/ijrm/article/view/4517/', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '29 May 2019', 'publication': 'International Journal of Reproductive BioMedicine (IJRM)', 'title': 'Differential expression of progesterone receptor isoforms related to PGR +331g/a polymorphism in endometriosis: A case-control study', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ijrm.v17i3.4517', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Sepideh Mousazadeh | Azadeh Ghaheri | Maryam Shahhoseini | Reza Aflatoonian | Parvaneh Afsharian', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ijrm.v17i3.4517 JSON XML

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endometriosis

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