Inhibition of steroid sulfatase activity in endometriotic implants by STX64 (667Coumate): a potential new therapy

L. Fusi, Luca Fusi, Fusi L, Purohit A, A. Purohit, Jan J. Brosens, J Brosens, Woo LW, L. W. Lawrence Woo, L W L Woo, Potter BV, B. V. L. POTTER, M J Reed, Michael Reed, Reed MJ
TheScientificWorldJournal · 2008 · vol. 8 , pp. 1325–1327 · doi:10.1100/tsw.2008.164 · PMID:19112542 · PMC5849069 · W2125898668
Other OA: gold CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated the inhibition of steroid sulfatase activity in endometriotic implants using STX64 (667Coumate), proposing it as a potential new therapy for endometriosis.

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Abstract

Endometriosis is a common and debilitating condition of women in their reproductive age that is associated with pain and infertility. Current medical treatments are only partially effective and associated with wide-ranging side effects. New understanding of local estrogen production by endometriotic tissue and the availability of powerful suppressing drugs may herald a new era in the treatment of this condition.

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Condition tags

endometriosisinfertility

MeSH descriptors

Coumarins Endometriosis Enzyme Inhibitors Steryl-Sulfatase Steryl-Sulfatase Sulfonamides Sulfonic Acids Adult Adult Coumarins Coumarins Coumarins Disease Progression Disease Progression Endometriosis Endometriosis Enzyme Inhibitors Enzyme Inhibitors Estrogens Estrogens

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (11)

Cited by (3)

Source provenance

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License: CC0 · commercial use OK