Inhibition of Steroid Sulfatase Activity in Endometriotic Implants by STX64 (667Coumate): A Potential New Therapy

L Fusi, Luca Fusi, A Purohit, J Brosens, Jan J. Brosens, L. W. Lawrence Woo, L W L Woo, B V L Potter, M J Reed, Michael Reed
TheScientificWorldJournal · 2008 · vol. 8 , pp. 1325–1327 · doi:10.1100/tsw.2008.164 · PMID:19112542 · PMC5849069 · W2125898668
article OA: gold CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the inhibition of steroid sulfatase activity in endometriotic implants using STX64 (667Coumate), proposing it as a potential new therapy for endometriosis.

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Abstract

Endometriosis is a common and debilitating condition of women in their reproductive age that is associated with pain and infertility. Current medical treatments are only partially effective and associated with wide-ranging side effects. New understanding of local estrogen production by endometriotic tissue and the availability of powerful suppressing drugs may herald a new era in the treatment of this condition.

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Condition tags

endometriosisinfertility

MeSH descriptors

Coumarins Endometriosis Enzyme Inhibitors Steryl-Sulfatase Steryl-Sulfatase Sulfonamides Sulfonic Acids Adult Coumarins Coumarins Disease Progression Endometriosis Enzyme Inhibitors Estrogens Estrogens Female Humans Ovary Ovary Steryl-Sulfatase

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

Cited by (3)

Source provenance

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