The Role of Chronic Endometritis in The Etiopathogenesis of Adenomyosis

Batuhan Aslan, Cevriye Cansız Ersöz, Ersöz CC, Yavuz Emre Şükür, Şükür YE, Batuhan Özmen, Özmen B, Murat Sönmezer, Sönmezer M, Berker B, Bülent Berker, Ruşen Aytaç, Aytaç R, Cem Somer Atabekoğlu, Atabekoğlu CS
In: Authorea Inc. · 2024 · doi:10.22541/au.171800026.66499319/v1 · W4399506338
Observational preprint OA: gold CC0
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study found a significant relationship between adenomyosis and chronic endometritis, particularly in patients with basal endometrial loss.

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Abstract

Objective: The aim of our study is to examine the relationship between adenomyosis and chronic endometritis and to discuss its possible effects on pathogenesis. Design: Prospective analysis of previous patients’ pathology specimens Setting: A tertiary university hospital’s department of obstetrics and gynecology. Patients: Patients who underwent hysterectomy at were divided into two groups according to the presence or absence of adenomyosis. A propensity score matching analysis was performed to minimize selection bias in patient groups. A total of 146, 73 patients in each group, were included in the study. Methods: The previous specimens of the patients were re-evaluated with the CD38 immunohistochemistry staining method. A positive diagnosis of CE was made in the presence of plasma cells. In particular, basal endometrial thickness was measured in endo-myometrial transition zones. Main outcome measures and Results: The adenomyosis group was significantly younger than the group without adenomyosis (47.14 ± 4.24 vs. 50.36 ± 7.02, p = 0.012). 17 (11.6%) patients in the adenomyosis group were diagnosed with chronic endometritis, while 7 (4.8%) patients in the control group were diagnosed with chronic endometritis, and a statistically significant difference was found (p<0.05). Basal endometrium could be measured in a total of 112 (76.7%) patients, while basal endometrial loss was observed in 34 (23.3%) patients. Chronic endometritis was found in 16 (47%) of the patients with basal endometrial loss. The baseline endometrial thickness of 112 (76.7%) of the patients could be measured, but only 8 (7.1%) of them had chronic endometritis. There was a statistically significant difference between the groups (p<0.001). In multivariate analysis, there was a statistically significant relationship between basal endometrial loss and CE. Conclusion(s): A significant relationship was observed between adenomyosis and chronic endometritis.

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adenomyosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (26)

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