Features of reproductive potential in patients with extensive endometriosis forms

D. M. Kalimatova, Yu. E. Dobrokhotova, M. D. Kazieva, I. Yu. Ilyina, J. M. Ibragimova
In: Obstetrics, Gynecology and Reproduction · 2026 · vol. 20(1) , pp. 91–101 · doi:10.17749/2313-7347/ob.gyn.rep.2026.676 · W7135404278
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study analyzed anti-Müllerian hormone levels and pregnancy rates in women with deep infiltrating endometriosis, finding age to be a key factor in reproductive potential.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This prospective cohort clinical trial studied 69 patients who underwent surgical treatment for extensive deep infiltrating endometriosis followed by 3 months of anti-relapse gonadotropin-releasing hormone agonist therapy, evaluating reproductive potential by measuring anti-Müllerian hormone (AMH) before surgery and 6 months afterward and tracking spontaneous pregnancy within 1 year. AMH declined in 51.8% of patients on average by 0.152 ng/mL, with the smallest reduction in women aged 28.5 to 33.5 years regardless of how extensive the surgery was; 10 of 43 women who planned pregnancy achieved spontaneous pregnancy (mean age 36.0 years). The paper’s limitation is that it focuses on AMH change and spontaneous pregnancy timing after a specific surgical plus short-term medical regimen, without reporting a control comparison group. Relevance to endometriosis: the study is centrally about extensive deep infiltrating endometriosis and uses AMH and pregnancy outcomes to characterize reproductive potential after surgical management.

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Abstract

Aim: to determine the optimal tactics for managing patients with deep infiltrating endometriosis. Materials and Methods . A prospective cohort clinical trial was conducted with 69 patients examined following surgical treatment for extensive infiltrating endometriosis and 3-month-long anti-relapse therapy with gonadotropin-releasing hormone agonists. Reproductive potential was assessed based on quantitating anti-Müllerian hormone (AMH) before and 6 months post-surgery, recording cases with/without onset of spontaneous pregnancy within 1 year. Results. While comparatively analyzing AMH level in preand postoperative period revealed its decline in 51.8 % by average 0.152 ng/ml; the smallest reduction was found in women aged 28.5 to 33.5 years, regardless of the extent of surgical treatment. Pregnancy occurred in 10 of 43 planning women (average age 36,0 [32,0–42,5] years): 7 patients underwent ovarian interventions, 3 – surgical treatment for endometriosis of other localizations. Conclusion. The data obtained evidence that subject’s age plays a decisive role in maintaining reproductive potential and a need for a differentiated approach in developing individual tactics for management and treatment of patients with deep infiltrating endometriosis, taking into account age, localization of endometriosis and reproductive plans.

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Condition tags

endometriosisdie_deep_infiltrating

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (27)

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last seen: 2026-06-13T20:58:58.657787+00:00
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