Medical treatment of endometriosis.

J A Garcia-Velasco, G Quea, Guillermo Quea
Minerva ginecologica · 2005 · vol. 57(3) , pp. 249–55 · PMID:16166934 · W107290794
article OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review outlines current medical treatments for endometriosis, focusing on hormonal suppression and targeted therapies, which moderately reduce pain but do not improve fertility.

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Abstract

The medical treatment of endometriosis is a critical aspect of the therapeutic approach to this disease. This review will present an overview of current literature about the medical treatment of endometriosis, without referring to the surgical treatment or a combination of both. The main purpose of the current medical treatment of endometriosis is to create an amenorrheic state, in other words, to create a hypoestrogenic environment by suppressing estrogen secretion of the ovary. Current research has focused upon medications designed to attack specific aspects of the development and maintenance of endometriosis. This includes progesterone receptor modulators, gonadotropin releasing hormone (GnRH) analogs, aromatase inhibitors and, tumor necrosis factor alpha (TNFalpha) inhibitors, angiogenesis inhibitors, matrix metalloproteinase inhibitors and estrogen receptor beta agonists like inmunomodulators. These drugs show decreased spreading of lesions and reduced disease related symptoms. Medical treatment is moderately effective in reducing pain but ineffective in improving fertility; a combination of medical treatment with assisted reproductive technology may be beneficial in improving fertility.

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Condition tags

dyspareuniaendometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Danazol Danazol Dyspareunia Dyspareunia Dyspareunia Endometriosis Endometriosis Estrogen Antagonists Estrogen Antagonists Female Gestrinone Gestrinone Humans Pelvic Pain Pelvic Pain Pelvic Pain Progestins Progestins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (9)

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License: CC0 · commercial use OK