[Serum and peritoneal fluid CA-125 concentration in women with endometriosis].

D Kraśnicki, Kraśnicki D
Ginekologia polska · 2001 · vol. 72(12A) , pp. 1365–9 · PMID:11883280 · W2399594092
article OA: closed CC0 ⤵ 8 in-corpus citations
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Peritoneal fluid CA-125 levels were significantly higher than serum levels and elevated in women with endometriosis, suggesting its utility for detecting the disease, especially in early stages.

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Abstract

OBJECTIVE: To evaluate the clinical utility of CA-125 measurements in peritoneal fluid (PF) as an indicator of endometriosis. DESIGN: CA-125 levels in paired serum and peritoneal fluid were assessed by IMx CA-125 Assay (ABBOTT). PATIENTS: 107 women with and without endometriosis, undergoing laparoscopy during the luteal phase of the menstrual cycle were selected for the study. RESULTS: CA-125 levels in peritoneal fluid were higher than those found in serum and were significantly elevated (P < 0.05) in comparison to the control group. In women with endometriosis stage I-II and stage III-IV. CA-125 levels in serum were increased only in stage III-IV. CONCLUSIONS: The sensitivity of the peritoneal fluid CA-125 test for endometriosis is higher than the respective serum test. The measurement of CA-125 levels in PF could be useful in the detection of the early stage endometriosis, which seems to be missed by the CA-125 serum test.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid CA-125 Antigen Endometriosis Adult Ascitic Fluid CA-125 Antigen CA-125 Antigen Case-Control Studies Endometriosis Endometriosis Female Humans Luteal Phase Luteal Phase Menstrual Cycle Menstrual Cycle Predictive Value of Tests Reproducibility of Results Sensitivity and Specificity

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