Danazol and fetal masculinization: a warning

A C Kingsbury; Andrew C. Kingsbury; Kingsbury AC

doi:10.5694/j.1326-5377.1985.tb123105.x

Danazol and fetal masculinization: a warning

A C Kingsbury, Andrew C. Kingsbury, Kingsbury AC

The Medical journal of Australia · 1985 · vol. 143(9) , pp. 410–411 · doi:10.5694/j.1326-5377.1985.tb123105.x · PMID:4058352 · W2413730473

Case report OA: closed CC0 ⤵ 3 in-corpus citations

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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

Danazol use during pregnancy for infertility has been linked to fetal masculinization, necessitating patient awareness and concurrent contraception to prevent exposure.

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Abstract

Masculinization of a female fetus occurred during a pregnancy in which the mother received danazol for infertility due to endometriosis. The biochemical theories and the necessary treatment are outlined. Conception may occur before or during a course of danazol, and patients should be made aware of the need for concomitant contraception.

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Condition tags

endometriosisinfertility

MeSH descriptors

Danazol Disorders of Sex Development Pregnadienes Danazol Danazol Disorders of Sex Development Disorders of Sex Development Disorders of Sex Development Female Female Fetus Fetus Fetus Genitalia, Female Genitalia, Female Genitalia, Female Humans Humans Infant Infant

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (12)

Danazol binding and translocation of steroid receptors via openalex
Danazol Inhibits Steroidogenesis via openalex
Danazol may cause female pseudohermaphroditism via openalex
Dosage aspects of danazol therapy in endometriosis: short-term and long-term effectiveness via openalex
Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol via openalex
Pituitary gonadotropin inhibitory activity of danazol via openalex
Transient adrenogenital syndrome due to exposure to danazol in utero via openalex
W2042869007 via openalex
W1491974427 via openalex
W2005632323 via openalex
W2007785687 via openalex
W2039265676 via openalex

Cited by (3)

Danazol 2006
Medical Therapy for Endometriosis 2003
The effects of fetal exposure to danazol 1992

Source provenance

europepmc: last seen: 2026-10-10T06:11:15.153948+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-10-08T21:50:14.112910+00:00

License: CC0 · commercial use OK

[1] Danazol binding and translocation of steroid receptors via openalex

[2] Danazol Inhibits Steroidogenesis via openalex

[3] Danazol may cause female pseudohermaphroditism via openalex

[4] Dosage aspects of danazol therapy in endometriosis: short-term and long-term effectiveness via openalex

[5] Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol via openalex

[6] Pituitary gonadotropin inhibitory activity of danazol via openalex

[7] Transient adrenogenital syndrome due to exposure to danazol in utero via openalex

[8] W2042869007 via openalex

[9] W1491974427 via openalex

[10] W2005632323 via openalex

[11] W2007785687 via openalex

[12] W2039265676 via openalex