Endometrioid adenocarcinoma presenting in a patient 18 years after hysterectomy: a potential hazard of unopposed oestrogen therapy
Case report
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⤵ 3 in-corpus citations
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This paper reports a case of endometrioid adenocarcinoma arising from extragonadal endometriosis 18 years post-hysterectomy, potentially linked to prolonged unopposed estrogen therapy.
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Abstract
We present a case of endometrioid adenocarcinoma arising from extragonadal endometriosis 18 years after total abdominal hysterectomy with bilateral salpingo-oophorectomy. After the primary surgery the patient received 11 years of unopposed oestrogen hormone replacement therapy. She presented with symptoms of urinary retention and pelvic mass. Following resection, histopathology identified the mass as an endometrioid adenocarcinoma. The association between persistent endometriosis and the development of endometrial cancer are discussed here together with the risks of unopposed oestrogen in the development of such lesions.
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References (11)
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- Cancer risk after a hospital discharge diagnosis of endometriosis via openalex
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- Malignancy arising in extraovarian endometriosis during estrogen stimulation via openalex
- Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis via openalex
- The familial risk of breast cancer in women with endometriosis from Yale series via openalex
- The relationship of endometriosis and ovarian malignancy: a review via openalex
- The risk of cancer and the role of parity among women with endometriosis via openalex
- W2053309322 via openalex
Cited by (4)
- Case Report: Malignant transformation of deep infiltrating endometriosis: a report of two cases and literature review 2026
- Two cases of extragonadal malignant transformation of endometriosis after TAH/BSO for benign indications 2019
- Malignant transformation of persistent endometriosis after hysterectomy 2014
- Extraluminal bowel obstruction by endometrioid adenocarcinoma 34 years post-hysterectomy: risks of unopposed oestrogen therapy 2011
Source provenance
- europepmc
- last seen: 2026-10-14T06:08:39.101224+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:09:19.025198+00:00
License: CC0
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