Accuracy of a new diagnostic tool in deep infiltrating endometriosis: Positron emission tomography-computed tomography with 16α-[18F]fluoro-17β-estradiol

Stefano Cosma, Matteo Salgarello, Salgarello M, Marcello Ceccaroni, Giancarlo Gorgoni, Francesca Riboni, La Paglia E, Ernesto La Paglia, Danese S, Saverio Danese, Benedetto C, Chiara Benedetto
Journal of Obstetrics and Gynaecology Research · 2016 · vol. 42(12) , pp. 1724–1733 · doi:10.1111/jog.13117 · PMID:27558211 · W2507969242
Other OA: closed CC0 ⤵ 16 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Positron emission tomography-computed tomography with 16α-[18F]fluoro-17β-estradiol demonstrated feasibility and higher accuracy than MRI for diagnosing deep infiltrating endometriosis, especially after prior surgery.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

AIM: Preoperative workup of deep infiltrating endometriosis is limited in the evaluation of extragenital and extrapelvic disease and in distinguishing between the previous surgical scar and active lesion. Histological verification remains the gold standard for diagnosis. The aim of this study was therefore to evaluate positron emission tomography-computed tomography (PET/CT) with an experimental estrogen receptor tracer (16α-[18F]fluoro-17β-estradiol; [18F]FES) for accurate staging and non-invasive diagnosis of the disease. The primary endpoint was the feasibility of this tool on comparison with histology. The secondary endpoint was the accuracy of PET/CT in comparison with magnetic resonance imaging (MRI). METHODS: Four eligible subjects with extragenital endometriosis underwent MRI, PET/CT with [18F]FES, and laparoscopic excision of endometriosis in the same month. Region-by-region analysis was used to compare the findings of the two diagnostic tools with surgical histological specimens obtained during laparoscopy. RESULTS: A total of 40 anatomical regions were examined: seven were [18F]FES positive, four were positive on MRI and eight positive on histology. A total of nine regions were discordant. PET/CT agreed with histology in 9/9 of the discrepant findings. CONCLUSION: PET/CT with [18F]FES was feasible and had greater accuracy than MRI, particularly in patients with previous surgery. Further studies are needed, however, to investigate its role in bowel endometriosis in sites other than recto-sigmoid junction, nerve localization, and subcentimetric disease.

My notes (saved in your browser only)

Condition tags

endometriosisdie_deep_infiltratingbowel_endometriosis

MeSH descriptors

Endometriosis Estradiol Positron Emission Tomography Computed Tomography Endometriosis Endometriosis Endometriosis Estradiol Estradiol Female Female Humans Humans Magnetic Resonance Imaging Magnetic Resonance Imaging Magnetic Resonance Imaging Positron Emission Tomography Computed Tomography Positron Emission Tomography Computed Tomography Quality of Life Quality of Life Sensitivity and Specificity

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (15)

Cited by (18)

Source provenance

europepmc
last seen: 2026-10-13T06:10:10.580696+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:18:26.654515+00:00
License: CC0 · commercial use OK