Treatment options for endometrial hypoproliferation

Yigit Cakiroglu, Yiğit Çakıroğlu, Bülent Tıraş, Bulent Tiras, Jason Franasiak, Jason M. Franasiak, Emre Seli
Current opinion in obstetrics & gynecology · 2023 · vol. 35(3) , pp. 254–262 · doi:10.1097/gco.0000000000000863 · PMID:36912320 · W4324017937
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This review discusses current endocrine, vitamin, and experimental strategies for treating endometrial hypoproliferation, a challenge in IVF despite undefined diagnostic criteria and the need for further research.

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Abstract

PURPOSE OF REVIEW: Endometrial hypoproliferation refers to the failure of the endometrium to reach optimal thickness during fresh or frozen embryo transfer cycles in women undergoing infertility treatment with in-vitro fertilization (IVF). This review discusses the treatment options for endometrial hypoproliferation. RECENT FINDINGS: Apart from factors related to the embryo quality, ultrasonographic findings associated with the endometrium, such as endometrial thickness, endometrial pattern and subendometrial blood flow, are considered key factors associated with the outcome of assisted reproductive treatment. To date, a consensus has not been reached regarding the definition of thin endometrium, while thresholds of 6, 7 or 8 mm have been used in the literature. Strategies to increase endometrial thickness can be reviewed in three groups: endocrine approaches, vitamins & supplements, and new experimental therapeutic interventions. Some of the recently introduced experimental therapeutic interventions such as platelet-rich plasma injection, stem cell treatment and tissue bioengineering are exciting potential therapies that need to be further studied. SUMMARY: Despite a large number of publications on the topic, diagnosing and treating endometrial hypoproliferation remains a challenge. Well designed studies are needed to establish a widely accepted endometrial thickness cut-off value below which endometrial hypoproliferation is diagnosed and to generate meaningful data that would allow an evidence-based discussion of available therapeutic options with patients.

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Condition tags

infertility

MeSH descriptors

Fertilization in Vitro Infertility, Female Infertility, Female Embryo Transfer Endometrium Female Humans Pregnancy Pregnancy Rate Reproduction

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (82)

Source provenance

openalex
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pubmed
last seen: 2026-10-08T21:39:06.473101+00:00
License: CC0 · commercial use OK