Do endometriomas grow during ovarian stimulation for assisted reproduction? A three-dimensional volume analysis before and after ovarian stimulation

Ayse Seyhan, Ayşe Seyhan, Urman B, Bulent Urman, Bülent Urman, Engin Turkgeldi, Engin Türkgeldi, Baris Ata, Barış Ata
Reproductive biomedicine online · 2017 · vol. 36(2) , pp. 239–244 · doi:10.1016/j.rbmo.2017.10.108 · PMID:29203384 · W2769888040
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This study analyzed three-dimensional volumes of endometriomas before and after ovarian stimulation to determine if they grow during assisted reproduction procedures.

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Abstract

Whether endometriomas grow because of supraphysiological oestradiol levels attained during ovarian stimulation for assisted reproduction techniques is a concern. In this prospective study, 25 women with 28 endometriomas underwent three-dimensional ultrasound using sono-automated volume calculation software. Endometrioma volume was measured on the first day of gonadotrophin injection (V1) and the day of ovulation trigger (V2). Nine (36%) women were stimulated in a gonadotrophin releasing hormone antagonist protocol (GnRH), 13 (52%) in a long, and three (12%) in an ultra-long GnRH agonist protocol. Mean duration of stimulation was 10.3 days with median total gonadotrophin dose of 4500 IU/day. Median number of cumulus oocyte complexes was five, and metaphase-two oocytes was four. None of the endometriomas were punctured during oocyte retrieval. Median V1 was 22.2 ml (12-30 ml) and median V2 was 24.99 ml (11.2-37.4 ml) with P = 0.001. Twenty-three out of 28 endometriomas (82%) grew to some extent during ovarian stimulation. Endometrioma growth was positively correlated with prestimulation cyst volume (Correlation coefficient 0.664; P < 0.01). Although the 3-ml average growth was statistically significant, it could be regarded as clinically insignificant.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovulation Induction Adult Female Humans Imaging, Three-Dimensional Ovulation Induction Prospective Studies Ultrasonography

Citation neighborhood

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References (17)

Cited by (12)

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