Endometriosis Progression and In Vitro Fertilization

In: Endometriosis-related Infertility · 2024 · pp. 249–267 · doi:10.1007/978-3-031-50662-8_19 · W4392309429
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This review examines case reports and series to understand if in vitro fertilization, with its hormonal stimulation, affects endometriosis progression, considering both estrogen and progesterone influences.

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This chapter reviews evidence on whether in vitro fertilization (IVF) influences endometriosis progression, drawing on initial case reports and subsequent retrospective and prospective case series assessing pain score changes and surgical evidence. It frames the biological rationale around IVF-associated supraphysiologic estrogen from gonadotropin stimulation and the counteracting effect of increased progesterone during IVF cycles, but emphasizes that the data come from varied study designs. A major caveat is that the chapter synthesizes heterogeneous evidence rather than presenting new pooled results, so conclusions must account for differences in outcomes and methods across reports. This paper is centrally about endometriosis — specifically how IVF and related hormonal stimulation may affect endometriosis progression.

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Abstract

This study investigates the role of in vitro fertilization on endometriosis progression. Endometriosis is a hormone-sensitive disease process. It was initially suggested by case reports that endometriosis progresses substantially with in vitro fertilization. This could be due to the supraphysiologic estrogen levels introduced by gonadotropin stimulation. However, progesterone counteracts the role of estrogen in endometriosis, possibly treating the lesions, and is also increased in IVF cycles. This chapter reviews the initial evidence based on case reports and the subsequent data from case series, both retrospective and prospective, to understand the role, if any of endometriosis progression from fertility care. The changes in pain scores and surgical evidence of endometriosis will be presented, such that the reader will develop expertise in this area of reproductive medicine. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

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Gérard N, Caillaud M, Martoriati A, et al. The interleuking-1 system and female reproduction. J Endocrinol. 2004;180:203–12. https://doi.org/10.1677/joe.0.1800203. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Mills, G., Dahan, M.H. (2024). Endometriosis Progression and In Vitro Fertilization. In: Ferrero, S. (eds) Endometriosis-related Infertility. Springer, Cham. https://doi.org/10.1007/978-3-031-50662-8_19 Download citation DOI: https://doi.org/10.1007/978-3-031-50662-8_19 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-50661-1 Online ISBN: 978-3-031-50662-8 eBook Packages: MedicineMedicine (R0)

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