Modern trends in the treatment of patients with endometriosis

M.I. Yarmolinskaya, A.S. Molotkov, E.M. Tsybuk
In: Russian Bulletin of Obstetrician-Gynecologist · 2026 · vol. 26(1) , pp. 110 · doi:10.17116/rosakush202626011110 · W7135067308
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This paper compares international guidelines on medical and surgical endometriosis treatments, finding no single universally effective strategy currently exists.

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This paper is a narrative overview of modern trends in treating patients with endometriosis, synthesizing guideline recommendations and evidence from clinical studies, including options for pelvic pain management, hormonal approaches, and considerations such as safety outcomes (e.g., bone mineral density in GnRH antagonists) and add-back therapy. Across the cited sources, it emphasizes evolving treatment strategies aligned with current clinical guidelines and contemporary targets for symptom control and related reproductive outcomes, rather than presenting new primary trial data. A major limitation is that it is a secondary, review-style treatment trends discussion dependent on heterogeneous publications and guideline statements rather than systematic, study-level comparative analyses. This paper is centrally about endometriosis — it summarizes modern treatment trends and evidence-based approaches for managing endometriosis-associated pain and related clinical issues.

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Abstract

Based on a comparative analysis of current methodological documents (manuals, guidelines) from international organizations, including the American Society for Reproductive Medicine (ASRM), the National Institute for Health and Care Excellence (NICE), the European Society of Human Reproduction and Embryology (ESHRE), and the Russian Federation (Russian Society of Obstetricians and Gynecologists, Ministry of Health of the Russian Federation), this paper presents current methods of medical (progestogens, gonadotropin-releasing hormone agonists) and surgical treatment of patients with endometriosis. Currently, a single, effective strategy for providing medical care for endometriosis that is suitable for all patients has not yet been approved.
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Сайт издательства «Медиа Сфера» содержит материалы, предназначенные исключительно для работников здравоохранения. Закрывая это сообщение, Вы подтверждаете, что являетесь дипломированным медицинским работником или студентом медицинского образовательного учреждения. Результаты поиска: 0 Современные тенденции в лечении больных эндометриозом Журнал: Российский вестник акушера-гинеколога. 2026;26(1): 110‑119 Прочитано: 429 раз Как цитировать: Литература / References: - Culley L, Law C, Hudson N, Denny E, Mitchell H, Baumgarten M, Raine-Fenning N. The social and psychological impact of endometriosis on women’s lives: a critical narrative review. Hum Reprod Update. 2013;19:6:625-639. https://doi.org/10.1093/humupd/dmt027 - Giudice LC, Oskotsky TT, Falako S, Opoku-Anane J, Sirota M. Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations. FASEB J. 2023;37:9:e23130. https://doi.org/10.1096/fj.202300907 - Bougie O, Yap MI, Sikora L, Flaxman T, Singh S. Influence of race/ethnicity on prevalence and presentation of endometriosis: a systematic review and meta-analysis. BJOG. 2019;126:9: 1104-1115. https://doi.org/10.1111/1471-0528.15692 - Simoens S, Dunselman G, Dirksen C, Hummelshoj L, Bokor A, Brandes I, Brodszky V, Canis M, Colombo GL, DeLeire T, Falcone T, Graham B, Halis G, Horne A, Kanj O, Kjer JJ, Kristensen J, Lebovic D, Mueller M, Vigano P, Wullschleger M, D’Hooghe T. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres [published correction appears in Hum Reprod. 2014;29:9:2073]. Hum Reprod. 2012;27:5:1292—1299. https://doi.org/10.1093/humrep/des073 - Simoens S, Hummelshoj L, Dunselman G, Brandes I, Dirksen C, D’Hooghe T; EndoCost Consortium. Endometriosis cost assessment (the EndoCost study): a cost-of-illness study protocol. Gynecol Obstet Invest. 2011;71:3:170-176. https://doi.org/10.1159/000316055 - Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility: a committee opinion. Fertil Steril. 2012;98:3:591-598. https://doi.org/10.1016/j.fertnstert.2012.05.031 - Practice Committee of the American Society for Reproductive Medicine. Treatment of pelvic pain associated with endometriosis: a committee opinion [published correction appears in Fertil Steril. 2015;104:2:498]. Fertil Steril. 2014;101:4:927-935. https://doi.org/10.1016/j.fertnstert.2014.02.012 - Endometriosis Guideline Development Group: Endometriosis. Guideline of European Society of Human Reproduction and Embryology. 2022. - Brown J, Crawford TJ, Allen C, Hopewell S, Prentice A. Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev. 2017;1:1:CD004753. Published 2017. https://doi.org/10.1002/14651858.CD004753.pub4 - Niringiyumukiza JD, Cai H, Xiang W. Prostaglandin E2 involvement in mammalian female fertility: ovulation, fertilization, embryo development and early implantation. Reprod Biol Endocrinol. 2018;16:1:43. https://doi.org/10.1186/s12958-018-0359-5 - Ярмолинская М.И., Денисова В.М. Современные подходы к назначению add-back-терапии больным генитальным эндометриозом Эффективная фармакотерапия. 2015;36:24-31. - Ярмолинская М.И., Хачатурян А.Р., Андреева Н.Ю., Пьянкова В.О. Современные возможности и перспективы применения пероральной формы антагонистов гонадотропин-рилизинг-гормона (обзор литературы). Проблемы репродукции. 2020;26:5:78-83. https://doi.org/10.17116/repro20202605178 - Carr B, Giudice L, Dmowski WP, O’Brien C, Jiang P, Burke J, Jimenez R, Hass S, Fuldeore M, Chwalisz K. Elagolix, an oral GnRH antagonist for endometriosis-associated pain: A Randomized controlled study. J Endometr Pelvic Pain Disord. 2013;5:3:105-115. - Bestel E, Humberstone A, Lecomte V, Loumaye E, Gotteland JP, Simon JA. The Effect of linzagolix on bone mineral density (BMD): Safety results from a dose-ranging trial [21J]. Obstetrics & Gynecology. 2019;133:112S-113S. https://doi.org/10.1097/01.AOG.0000558837.48634.b6 - Молотков А.С., Ярмолинская М.И. Результаты применения ингибитора ароматазы в лечении больных наружным генитальным эндометриозом. Журнал акушерства и женских болезней. 2016; 65:56-57. - Ярмолинская М.И., Молотков А.С., Беженарь В.Ф. Способ комплексного лечения наружного генитального эндометриоза. Патент на изобретение RU 2541089 C1, 10.02.2015. Заявка №2013152127/15 от 22.11.2013. - Endometriosis: diagnosis and management. London: National Institute for Health and Care Excellence (NICE); 2024, Nov 11. PMID 38815122. - Эндометриоз. Клинические рекомендации. М. 2024. https://cr.minzdrav.gov.ru/schema/259_1 - Эндометриоз: диагностика, лечение и реабилитация: Клинические рекомендации. М. 2016. https://zdrav.spb.ru/media/filebrowser/%D1%8D%D0%BD%D0%B4%D0%BE%D0%BC%D0%B5%D1%82%D1%80%D0%B8%D0%BE%D0%B7_%D0%B4%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%C2%AD%D1%81%D1%82%D0%B8%D0%BA%D0%B0%2C_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5_%D0%B8_%D1%80%D0%B5%D0%B0%D0%B1%D0%B8%D0%BB%D0%B8%D1%82%D0%B0%D1%86%D0%B8%D1%8F.pdf - Сухих Г.Т., Серов В.Н., Адамян Л.В., Баранов И.И., Беженарь В.Ф., Габидуллина Р.И., Дубровина С.О., Козаченко А.В., Подзолкова Н.М., Сметник А.А., Тапильская Н.И., Уварова Е.В., Ших Е.В., Ярмолинская М.И. Алгоритмы ведения пациенток с эндометриозом: согласованная позиция экспертов Российского общества акушеров-гинекологов. Акушерство и гинекология. 2023;5:159-176. https://doi.org/10.18565/aig.2023.132 - Ярмолинская М.И., Адамян Л.В. Гормональные контрацептивы и эндометриоз: современный взгляд на проблему. Проблемы репродукции. 2020;26:3:39-45. https://doi.org/10.17116/repro20202603139 - Женское бесплодие: клинические рекомендации. 2021. https://roag-portal.ru/recommendations_gynecology - Lee HJ, S-H Yoon, JH Lee, Y-J Chung, SY Park, Kim SW, Hong YH, Kim SE, Kim Y, Chun S, Na YJ. Clinical evaluation and management of endometriosis: 2024 guideline for Korean patients from the Korean Society of Endometriosis. Obstet Gynecol Sci. 2025;68:1:43-58. https://doi.org/10.5301/je.5000157 Подтверждение e-mail На [email protected] отправлено письмо со ссылкой для подтверждения e-mail. Перейдите по ссылке из письма, чтобы завершить регистрацию на сайте. Подтверждение e-mail Мы используем файлы cооkies для улучшения работы сайта. Оставаясь на нашем сайте, вы соглашаетесь с условиями использования файлов cооkies. Чтобы ознакомиться с нашими Положениями о конфиденциальности и об использовании файлов cookie, нажмите здесь.

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endometriosis

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