Serum Ca-125 concentrations in endometriosis.
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Serum Ca-125 was significantly higher in stages III and IV endometriosis patients, but its low sensitivity limits its diagnostic use, though high values may indicate surgical exploration.
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Abstract
Serum Ca-125 levels were measured in 154 patients undergoing laparoscopy or laparotomy for infertility and/or pelvic pain. Pelvic endometriosis at various stages was observed in 102 of the patients, and 52 had a visually normal pelvis and served as a control group. We found a significantly higher mean serum Ca-125 concentration in the patients with stages III and IV endometriosis compared with the controls (P less than 0.001) whereas in the patients with stages I and II disease the mean antigen level was comparable to that of the control group. Considering its low sensitivity (14.7%) the usefulness of serum Ca-125 measurements as an initial diagnostic test for endometriosis is scanty. On the contrary, because of its elevated specificity (100%), this test may be useful in indicating early surgical exploration of the pelvis in cases of infertility and/or dysmenorrhea which are associated with high values of Ca-125.
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Cited by (6)
- Correlation of CA-125 with different stages of endometriosis 2018
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis 2016
- CA 125 serum values in surgically treated endometriosis patients and its relationships with anatomic sites of endometriosis and pregnancy rate 2010
- Usefulness and limits of CA-125 in diagnosis of endometriosis without associated ovarian endometriomas 2005
- The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis 1998
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