Bone loss in young women with karyotypically normal spontaneous premature ovarian failure

James N. Anasti, J N Anasti, S N Kalantaridou, L M Kimzey, R A Defensor, L M Nelson
Obstetrics & Gynecology · 1998 · vol. 91(1) , pp. 12–15 · doi:10.1016/s0029-7844(97)00583-8 · PMID:9464713 · W2028236696
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Sixty-seven percent of young women with karyotypically normal spontaneous premature ovarian failure had femoral neck bone mineral density more than one standard deviation below the mean of a reference group.

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Abstract

OBJECTIVE: To evaluate the effects of karotypically normal spontaneous premature ovarian failure on femoral neck bone mineral density. METHODS: Eighty-nine women with karyotypically normal spontaneous premature ovarian failure who desired fertility were evaluated at a tertiary care academic center and underwent hip and spinal bone density measurements by conventional dual-photon absorptiometry. Seventy-seven of the women (87%) had sought medical advice previously and had taken a variety of estrogen and progestin replacement regimens at least intermittently. The median (range) age was 32 (20-39) years, and the median (range) time since diagnosis was 1.5 (0.5-11) years. Findings were compared with a reference group of 218 regularly menstruating women of similar age. RESULTS: Sixty of the 89 women with premature ovarian failure (67%, 95% confidence interval 57, 77) had a femoral neck bone mineral density more than 1 standard deviation (SD) below the mean of the reference group (P < .001, chi2 with Yates correction). Even in women in whom the bone mineral density measurement was made within just 1.5 years of the diagnosis, nearly one-half (47%) had a femoral neck bone mineral density more than 1 SD below the mean of the reference group (P < .01). CONCLUSION: Two-thirds of young women with karyotypically normal spontaneous premature ovarian failure have a femoral neck bone mineral density more than 1 SD below the mean of a reference group. These young women need early education regarding strategies to maintain their bone mass and ongoing medical evaluation to maintain compliance with these strategies.

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MeSH descriptors

Bone Density Bone Resorption Femur Neck Primary Ovarian Insufficiency Spine Absorptiometry, Photon Adult Body Mass Index Bone Density Bone Resorption Bone Resorption Female Femur Neck Femur Neck Humans Karyotyping Primary Ovarian Insufficiency Primary Ovarian Insufficiency Primary Ovarian Insufficiency Prospective Studies

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