Bone mineral density in patients with primary ovarian insufficiency: A systematic review and Meta-Analysis

Mei Jiang, Ying Gao, Hongping Hou, Jing Guo, Wenyuan Li, Tianyu Qin, Minglu Shi, Ling Huang
In: European Journal of Obstetrics & Gynecology and Reproductive Biology · 2024 · vol. 295 , pp. 219–227 · doi:10.1016/j.ejogrb.2024.02.013 · PMID:38387304 · W4391722350
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This systematic review and meta-analysis of ten studies found significantly decreased bone mineral density in the femur neck and forearm of women with primary ovarian insufficiency compared to controls.

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Abstract

IntroductionPremature menopause is a major complication of primary ovarian insufficiency (POI), and this loss is closely relates to bone mineral density (BMD). Previous research has indicated potential associations between BMD and POI. This study set out to provide the first systematic literature review and meta-analysison account of BMD content among women with POI.MethodsStudies including women with POI and controls were eligible from PubMed, Embase, Cochrane Library and Web of Science databases (from their inception to April 2022). Two reviewers independently evaluated study eligibility. The meta-analysis was performed using the DerSimonian and Laird random effects model.ResultsTen studies featuring 578 women with POI and 480 controls were selected. BMD content of femur neck (SMD:-0.76; 95 % CI: -1.20 to -0.31; P = 0.0008), the BMD content of nondominating forearm (SMD:-0.67; 95 % CI: -1.15 to -0.18; P = 0.007) were significantly decreased in women with POI. However, no differences were seen in other regions (lumbar spine, total hip, hipneck).DiscussionThe results of this study indicate that BMD content altered in patients with primary ovarian insufficiency. An implication of this is the possibility that hormone replacement therapy to minimize the prevalence of fracture morbidity and mortality associated with osteopenia in patients with POI.

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