Polycystic ovary syndrome: Endometrial markers

Terhi Piltonen, Terhi T Piltonen
Best practice & research. Clinical obstetrics & gynaecology · 2016 · vol. 37 , pp. 66–79 · doi:10.1016/j.bpobgyn.2016.03.008 · PMID:27156350 · W2346727301
Review OA: closed CC0 ⤵ 5 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This review focuses on polycystic ovary syndrome (PCOS) and its relationship with endometrial markers.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Women with polycystic ovarian syndrome (PCOS) present with several endometrial abnormalities possibly explaining some of the adverse endometrium-related outcomes in these women. PCOS and an increased miscarriage rate have been suggested to coincide, but the results are conflicting. Recent studies have also shown increased risks of pregnancy-induced hypertension, preeclampsia, and premature delivery that may be related to altered decidualization/placentation in affected women. In the long run, PCOS per se is associated with the occurrence of endometrial cancer (EC), with obesity aggravating the risk. Most investigated markers of the endometrial abnormalities in women with PCOS are related to steroid hormone action (ERs (estrogen receptors), PRs (progesterone receptors), ARs (androgen receptors), and steroid receptor coactivators), endometrial receptivity/decidualization (HOXA10, αvβ3 integrin, and IGFBP-1 (insulin-like growth factor-binding protein 1)), glucose metabolism (IRs (insulin receptors), glucose transporters, IGFs) and inflammation/immune cell migration ((IL-6 (interleukin 6), CCL2 (CC motif ligand), and uNK (uterine natural killer) cells). Despite several endometrial abnormalities in women with PCOS, the clinical relevance of these findings still awaits future clarification; to date, no common screening protocols/recommendations for women with PCOS have been established.

My notes (saved in your browser only)

MeSH descriptors

Endometrial Neoplasms Endometrium Polycystic Ovary Syndrome Pregnancy Complications Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Antigens, CD Antigens, CD Chemokine CCL2 Chemokine CCL2 Embryo Implantation Endometrial Neoplasms Endometrial Neoplasms Endometrium Female Glucose Transport Proteins, Facilitative Glucose Transport Proteins, Facilitative Homeobox A10 Proteins Homeodomain Proteins

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (100)

Cited by (3)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:17:51.490942+00:00
unpaywall
last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0 · commercial use OK