Sertraline in the Treatment of Depression Associated with Gonadotropin-Releasing Hormone Agonist Therapy
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This study investigated the efficacy of sertraline in treating depression in patients undergoing gonadotropin-releasing hormone agonist therapy for prostate cancer.
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Abstract
BackgroundEndometriosis is thought to affect 5-10% of reproductive age women in the general population and is commonly treated with gonadotropin-releasing hormone (GnRH) agonists. Recent studies suggest depressive symptoms are associated with women treated with GnRH agonist for endometriosis.MethodsA retrospective pilot study of 42 female patients, 22 in the treatment group (sertraline) and 20 in the control group (no sertraline), was conducted. All subjects had laproscopically diagnosed endometriosis and were treated with 24 weeks of GnRH agonist therapy. Assessment instruments included the Hamilton Depression Rating Scale and the Menopausal Symptom Index.ResultsThe results indicate that patients receiving concomitant sertraline reported significantly less depressive symptoms, but did not differ significantly in physical symptoms than the group receiving a GnRH agonist alone.ConclusionsAntidepressants, such as sertraline, appear to be significantly helpful in the treatment of mood symptoms during the course of GnRH agonist therapy.
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References (9)
- Anxiety and mood disorders associated with gonadotropin-releasing hormone agonist therapy. via openalex
- Endometriosis: Current Management via openalex
- Goserelin (Zoladex) versus danazol for endometriosis via openalex
- Goserelin (Zoladex) versus danazol for endometriosis: the North American experience via openalex
- Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist. via openalex
- Uses of GnRH Agonists via openalex
- W2114613490 via openalex
- W2417044776 via openalex
- W6607058909 via openalex
Cited by (9)
- The Importance of a Multi-Disciplinary Approach to the Endometriotic Patients: The Relationship between Endometriosis and Psychic Vulnerability 2021
- Endometriosis and Infertility: The Impact on Quality of Life and Mental Health 2017
- Psychosomatic Aspects 2011
- Prevalence of depression in women with endometriosis 2007
- Intervenção multiprofissional em grupo as mulheres com endometriose 2007
- Depression in women with endometriosis with and without chronic pelvic pain 2006
- Avaliação da prevalencia de depressão em mulheres com endometriose atraves do BDI 2003
- Prevention of bone loss and hypoestrogenic symptoms by estrogen and interrupted progestogen add-back in long-term GnRH-agonist down-regulated patients with endometriosis and premenstrual syndrome 2002
- Avaliação da freqüência de depressão em pacientes com endometriose e dor pélvica 2002
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- europepmc
- last seen: 2026-08-10T06:11:17.106188+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:10:40.754221+00:00
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