Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs
This study investigated the absolute oral bioavailability of nanocrystalline danazol compared to a microcrystalline suspension in beagle dogs to assess the impact of particle size reduction.
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References (10)
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Cited by (19)
- Danazol 2022
- Molecular Dynamics Simulations Reveal Membrane Interactions for Poorly Water-Soluble Drugs: Impact of Bile Solubilization and Drug Aggregation 2020
- Danazol oral absorption modelling in the fasted dog: An example of mechanistic understanding of formulation effects on drug pharmacokinetics 2019
- Effect of cyclodextrin concentration on the oral bioavailability of danazol and cinnarizine in rats 2016
- Enhanced bioavailability of danazol nanosuspensions by wet milling and high-pressure homogenization 2016
- Application of Capmul MCM and caprylic acid for the development of danazol-loaded SEDDS 2014
- Evaluation of a Nanoemulsion Formulation Strategy for Oral Bioavailability Enhancement of Danazol in Rats and Dogs 2013
- Formulation of a Danazol Cocrystal with Controlled Supersaturation Plays an Essential Role in Improving Bioavailability 2013
- Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation (HGAP) Method 2009
- Supersaturation Produces High Bioavailability of Amorphous Danazol Particles Formed by Evaporative Precipitation into Aqueous Solution and Spray Freezing into Liquid Technologies 2006
- Supersaturation Produces High Bioavailability of Amorphous Danazol Particles Formed by Evaporative Precipitation into Aqueous Solution and Spray Freezing into Liquid Technologies 2006
- Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug 2005
- Rapid Dissolution of High‐Potency Danazol Particles Produced by Evaporative Precipitation into Aqueous Solution 2004
- Stable Amorphous Danazol Nanostructured Powders with Rapid Dissolution Rates Produced by Spray Freezing into Liquid 2004
- Rapid release tablet formulation of micronized danazol powder produced by spray-freezing into liquid (SFL) 2004
- Rapid dissolving high potency danazol powders produced by spray freezing into liquid process 2003
- Preparation and coating of finely dispersed drugs 2003
- Development and in vivo evaluation of buccal tablets prepared using danazol–sulfobutylether 7 β‐cyclodextrin (SBE 7) complexes 2002
- Relative bioavailability of danazol in dogs from liquid-filled hard gelatin capsules 1999
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