Polyglycolic acid/chitosan glue and apoptosis of endometriotic cells

Wang YC, Yu-Chi Wang, Ru‐Huei Fu, Ru-Huei Fu, Hsieh HJ, Hsyue-Jen Hsieh, Hsiang-Tai Chao, Chao HT, Shu-Huei Kao, Shu‐Huei Kao
Fertility and sterility · 2005 · vol. 84(1) , pp. 75–81 · doi:10.1016/j.fertnstert.2005.01.127 · PMID:16009160 · W2141111772
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This study investigated the effect of a polyglycolic acid/chitosan glue on endometriotic cell apoptosis, finding that the glue induced cell death in these cells.

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Abstract

OBJECTIVE: To induce apoptosis of endometriotic cells of patients with endometriosis. DESIGN: To demonstrate that polyglycolic acid/chitosan glue directly inhibits cell proliferation by inducing apoptosis. SETTING: University hospital infertility center. PATIENT(S): Twelve women who visited the center for infertility therapy. INTERVENTION(S): Polyglycolic acid/chitosan glue was applied into primary endometriotic cells; the manipulated cells were collected 1-4 days after polyglycolic acid/chitosan glue treatment. MAIN OUTCOME MEASURE(S): Primary endometriotic cell cultures from eutopic endometriotic tissue were established. The effect of the novel biological glue, polyglycolic acid/chitosan glue A, on endometrial cells in vitro was examined. The different stages of apoptosis were analyzed using flow cytometry with fluorescein isothiocyanate conjugate (FITC)-annexin V and propidium iodide staining. RESULT(S): The growth inhibitory effects of polyglycolic acid/chitosan glue A on endometrial cells were found to be dose-response and time dependent. Less than 15% viability was detected in cultures containing 2,000 microg of polyglycolic acid/chitosan glue A after 4 days of treatment. Induced apoptosis and caspase activity were revealed. The caspase-3 activity increased 2.2-fold with 4 days of culture with 2,000 microg of polyglycolic acid/chitosan glue A. CONCLUSION(S): This is the first study to demonstrate that polyglycolic acid/chitosan glue directly inhibits cell proliferation by inducing apoptosis, thus suggesting that this new biological glue may be useful for endometriosis therapy.

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Chitosan Endometrium Endometrium Polyglycolic Acid Apoptosis Apoptosis Apoptosis Cell Proliferation Cell Proliferation Cell Proliferation Cells, Cultured Cells, Cultured Chitosan Chitosan Dose-Response Relationship, Drug Dose-Response Relationship, Drug Endometriosis Endometriosis Endometriosis

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