What are the most significant challenges in understanding and managing endometriosis today?

Sakhr Alshwayyat, Karam Maraqa, Nihad A. Almasri, Noor Almasri, Salsabeel Aljawabrah, Shatha Abu Samrah, Layan Muwafaq Alzoubi, Shahed Nasser, Yamen Alshwaiyat, Joud Abu-Khass, Shahed Al-Ghsoon, Alzahra’a Al Matairi, Tala Al‐Saghir, Mohammed Al‐mahdi Al‐kurdi
In: Journal of Endometriosis and Pelvic Pain Disorders · 2025 · vol. 18(1) , pp. 33–54 · doi:10.1177/22840265251358904 · W4414510343
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This review consolidates recent findings on complex genetic and immunological factors, diagnostic and therapeutic advancements, and integrated care needs to address significant challenges in endometriosis management.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-17 · read from full text ⓘ

This paper is a narrative, question-focused review that addresses what the authors consider the most significant challenges in understanding and managing endometriosis, published in the Journal of Endometriosis and Pelvic Pain Disorders. It does not provide a study population, primary experimental methods, or quantitative results in the text provided, and its “conclusion” is not specified beyond the high-level framing. A key limitation evident from the provided content is that the actual abstract and methodological details are not included, preventing assessment of how the challenges were selected or categorized. This paper is centrally about endometriosis — it specifically discusses major challenges in understanding and managing the condition.

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Abstract

Background: Endometriosis remains a significant challenge to women’s health, with delays in diagnosis and suboptimal outcomes. This review aimed to consolidate recent findings and guide future strategies for improved detection, treatment, and patient care. Methods: A literature review was conducted using the PubMed and Cochrane Library databases. We included studies published in 2023 or later that evaluated epidemiological data, diagnostic biomarkers, and therapeutic interventions. Particular attention was given to emerging modalities, such as artificial intelligence-driven diagnostics, novel hormonal treatments, and integrative care approaches. Results: Recent findings underscore the complex genetic and immunological factors that contribute to the progression of endometriosis. Symptom normalization and limited clinician awareness can lead to delayed diagnosis, which worsens patient outcomes. Biomarkers and advanced imaging techniques show promise for earlier detection but lack standardization and universal availability. Hormonal therapies remain the cornerstone of treatment, whereas surgical approaches offer symptomatic relief and fertility benefits, albeit with risks such as recurrence and potential ovarian reserve reduction. Moreover, mental and medical comorbidities further exacerbate disease burden and underscore the need for integrated healthcare. Innovative options, including neuromodulation, mTOR inhibitors, and integrative pain management methods, are being actively investigated. Socioeconomic and cultural disparities compose access challenges, emphasizing the importance of multidisciplinary, patient-centered management. Conclusion: Major gaps remain in the early detection, comprehensive management, and equitable access for endometriosis. This review highlights the need for refined diagnostic tools, advanced treatment approaches, and integrated care strategies. Ongoing research and multidisciplinary collaboration are essential for improving patient outcomes and quality of life.
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Article versions Authors Author contributions Metrics and citations Metrics Journals metrics This article was published in Journal of Endometriosis and Pelvic Pain Disorders. View All Journal MetricsPublication usage* Total views and downloads: 262 *Publication usage tracking started in December 2016 Publications citing this one Receive email alerts when this publication is cited Web of Science: 0 Crossref: There are no citing articles to show. Figures and tables Figures & Media Tables View Options Access options If you have access to journal content via a personal subscription, university, library, employer or society, select from the options below: loading institutional access options Alternatively, view purchase options below: Purchase 24 hour online access to view and download content. Access journal content via a DeepDyve subscription or find out more about this option.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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