Fulminant hepatitis in a patient with hepatocellular carcinoma related to nonalcoholic steatohepatitis treated with sorafenib

Giovanni Brandi, Raden Muharam, Achmad Kemal Harzif, Stefania De Lorenzo, Stefania Di Girolamo, Catherine Catherine, Asmarinah Asmarinah, Stefano Bellentani, Budi Wiweko, Gioconda Saccoccio, Guido Biasco
Tumori · 2015 · vol. 8(3) , pp. 106–110 · doi:10.5301/je.5000247 · PMID:25702656 · W1990993131
Case report OA: closed CC0 ⤵ 4 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study found that the HOXA10 gene in eutopic endometrium exhibits higher methylation levels in endometriosis patients experiencing infertility compared to fertile controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

We describe a case of acute liver failure in a patient with advanced hepatocellular carcinoma related to nonalcoholic steatohepatitis during sorafenib treatment. A 74-year-old man with diabetes mellitus and hypertension was diagnosed with hepatocellular carcinoma associated with fatty liver. Three weeks after sorafenib therapy, at Eastern Cooperative Oncology Group performance status 3, he developed jaundice, general weakness, flapping tremor, nausea, and anorexia. Sorafenib was stopped: laboratory tests showed a relevant elevation of transaminases suggesting diagnosis of acute hepatitis. During hospital admission, the patient died of liver failure. Sorafenib is the first successful target therapy effective for advanced hepatocellular carcinoma. The most common adverse events are fatigue, hand-foot skin reaction, skin rash/desquamation, diarrhea, and hypertension, whereas liver dysfunction is uncommon. To our knowledge, this is the first patient reported in the literature with hepatocellular carcinoma related to nonalcoholic steatohepatitis who died of rapid worsening of liver function during sorafenib treatment.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

Antineoplastic Agents Carcinoma, Hepatocellular Liver Failure, Acute Liver Neoplasms Niacinamide Non-alcoholic Fatty Liver Disease Phenylurea Compounds Protein Kinase Inhibitors Aged Antineoplastic Agents Antineoplastic Agents Carcinoma, Hepatocellular Carcinoma, Hepatocellular Carcinoma, Hepatocellular Carcinoma, Hepatocellular Fatal Outcome Humans Jaundice Jaundice Liver Failure, Acute

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (35)

Cited by (4)

SciLite annotations

chemicals 5
sorafenib sorafenib sorafenib sorafenib sorafenib

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:15:04.544443+00:00
scilite
last seen: 2026-05-18T04:25:29.313245+00:00
unpaywall
last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0 · commercial use OK