Methylation Profile of HOXA 11 Gene in Eutopic Endometrium on Endometriosis Patient with Infertility

Muharam Natadisastra, Raden Muharam, Valencia Yuwono, Ririn Rahmala Febri, Asmarinah Asmarinah
In: Indonesian Journal of Obstetrics and Gynecology · 2018 · pp. 110 · doi:10.32771/inajog.v6i2.771 · W2897562901
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This study found significant hypermethylation of the HOXA11 gene in the eutopic endometrium of Indonesian women with endometriosis and infertility compared to fertile controls.

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Abstract

Objective: To investigate the HOXA11 gene profile on endometriosispatients with infertility in Indonesia.Methods: This cross sectional study was conducted in Dr. CiptoMangunkusumo Hospital from July 2015- June 2016. The subjectswere endometriosis patients with infertility who have beenconfirmed histopathological. The control group was taken fromnon-endometriosis and fertile patients. Eutopic endometriumsamples were taken and examined for the methylation of HOXA 11gene.Results: Both groups consist of six patients. The difference ofmethylation of HOXA 11 gene between those two groups isstatistically significant (p=0.03). There was hyper methylation inendometriosis group.Conclusion: There is a hyper methylation of HOXA 11 gene ineutopic endometrium of endometriosis patients with infertility.Thus, possibly can explain the poor endometrial receptivityin endometriosis patient and give a broad research area inepigenetic therapy of endometriosis.[Indones J Obstet Gynecol 2018; 6-2: 110-113]Keywords: endometriosis, epigenetic, HOXA 11, infertility,methylation

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endometriosisinfertility

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