A Preliminary Communication: Ongoing Study on HOXA10 Methylation Profile of Endometriosis Patients with Infertility

Raden Muharam, Achmad Kemal Harzif, Catherine Catherine, Asmarinah Asmarinah, Budi Wiweko
In: Journal of Endometriosis and Pelvic Pain Disorders · 2015 · vol. 8(3) , pp. 106–110 · doi:10.5301/je.5000247 · PMID:25702656 · W1990993131
article OA: closed CC0 ⤵ 4 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study found that the HOXA10 gene in eutopic endometrium exhibits higher methylation levels in endometriosis patients experiencing infertility compared to fertile controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Background Endometriosis and infertility have been shown to be related to one another. The mechanisms that explain this phenomenon are not fully understood. One of the possible mechanisms of infertility in endometriosis patients is failure of implantation of the embryo in the endometrium. This may be caused by high levels of methylation of HOXA10 gene in patients with endometriosis, resulting a decrease in the expression of genes that play a role in this endometrial receptivity. Objective To determine the methylation profile of HOXA10 gene on eutopic endometrium in endometriosis patients with infertility. Methods This is a cross-sectional study conducted at Cipto Mangunkusumo General Hospital from July 2015 to July 2016. The subjects of research were cystic ovarian endometriosis patients with infertility, confirmed histopathologically and non-endometriosis-fertile patients. The methylation status of HOXA 10 gene in both groups was examined and compared. Statistical analysis is Mann-Whitney U-test, a two-tailed p value less than 0.05 was considered significant. Results There were six endometriosis patients and six controls. Six samples on endometriosis group showed the following percentage rate of methylation: 63.29%, 55.28%, 33.92%, 43.27%, 77.20% and 65.94%. Meanwhile, four samples in the control group did not undergo methylation at all and two other samples methylated at low levels equal to 15.24% and 16.48%. Methylation status between these two groups is statistically different with p 0.03. Conclusions In patients with endometriosis-associated infertility, HOXA10 gene in eutopic endometrium has a higher methylation level.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (35)

Cited by (4)

SciLite annotations

chemicals 5
sorafenib sorafenib sorafenib sorafenib sorafenib

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
scilite
last seen: 2026-05-18T04:25:29.313245+00:00
License: CC0 · commercial use OK