Prepregnancy antiinflammatory diet in pregnant women with endometriosis: The Japan Environment and Children's Study

Kyozuka H, Hyo Kyozuka, Hidekazu Nishigori, Nishigori H, Murata T, Tsuyoshi Murata, Toma Fukuda, Fukuda T, Akiko Yamaguchi, Yamaguchi A, Kanno A, Aya Kanno, Yasuda S, Shun Yasuda, Sato A, Akiko Satô, Akiko Sato, Yuka Ogata, Kuse M, Masahito Kuse, Mitsuaki Hosoya, Hosoya M, Seiji Yasumura, Yasumura S, Koichi Hashimoto, Hashimoto K, Fujimori K, Keiya Fujimori, Japan Environment and Children's Study (JECS) Group
Nutrition (Burbank, Los Angeles County, Calif.) · 2021 · vol. 85 , pp. 111129 · doi:10.1016/j.nut.2020.111129 · PMID:33545538 · W3014701261
article OA: closed CC0 ⤵ 5 in-corpus citations
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This study investigated the association between adherence to an anti-inflammatory diet before pregnancy and endometriosis in pregnant women.

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Abstract

ObjectivesIncreased risk of preterm birth (PTB) in women with endometriosis is considered to be associated with chronic inflammatory conditions. Accordingly, we hypothesized that a prepregnancy antiinflammatory diet is a potential form of preconception care for preventing PTB in women with endometriosis and conducted this study to investigate the correlation of a prepregnancy antiinflammatory diet with obstetric outcomes in this patient population.MethodsWe used singleton pregnancy data from the Japan Environment and Children's Study involving live births from 2011 to 2014. Individual meal patterns before pregnancy, derived through food frequency questionnaires, were used to calculate the Dietary Inflammatory Index. Participants were categorized according to Dietary Inflammatory Index quintiles (Q1 and Q5 were the most proinflammatory and antiinflammatory groups, respectively), and a multiple logistic regression model was used to estimate the effect of the antiinflammatory diet on PTB before 37 or 34 wk and on low birth weight (LBW) <2500 or 1500 g.ResultsIn women who did not undergo assisted reproduction, significantly reduced risk was found in the Q5 group for both PTB at <34 wk significantly decreased (adjusted odds ratio, 0.25; 95% confidence interval, 0.07-0.83) and low birth weight <1500 g (adjusted odds ratio, 0.07; 95% confidence interval, 0.01-0.60).ConclusionsThis study suggests a distinct effect of an antiinflammatory diet on more severe obstetric outcomes, specifically PTB before 34 wk and low birth weight <1500 g, for women with endometriosis. Preconception lifestyle can improve perinatal mortality and morbidity among these women.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Premature Birth Premature Birth Premature Birth Child Diet Female Humans Infant, Newborn Japan Japan Live Birth Pregnancy Pregnant People Risk Factors

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