Neurokinin 1 receptor gene polymorphism might be correlated with recurrence rates in endometriosis

Stefan P. Renner, Arif B. Ekici, Maihöfner C, Christian Maihöfner, Peter Oppelt, Oppelt P, Thiel FC, Falk C. Thiel, Schrauder M, Michael Schrauder, Uenluehan N, Nesrin Uenluehan, Mayada R. Bani, Bani MR, Pamela L. Strissel, Strissel PL, Reiner Strick, Matthias W. Beckmann, Beckmann MW, Fasching PA, Peter A. Fasching
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2009 · vol. 25(11) , pp. 726–733 · doi:10.3109/09513590903159631 · PMID:19903051 · W2076661261
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This study found that the NK1R-SNP rs811 polymorphism was an independent predictor of disease-free survival, associating it with a lower recurrence risk in endometriosis patients.

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Abstract

INTRODUCTION: Dysmenorrhoea is the major symptom in women with endometriosis. Recently, pain modulation through Neurokinin-1-receptor (NK1R) pathways have been investigated in neuropathic pain patients. Aim of this study was, therefore, to examine the effect of a single nucleotide polymorphism (SNP) of the NK1R gene on the susceptibility for endometriosis and the disease free survival (DFS) after surgery for endometriosis. MATERIAL AND METHODS: A case-control study was conducted and germline DNA was isolated. Patients were followed up for a recurrence of the disease up to 4 years. Case-control analyses were performed for parameters of the medical history and the genotype of the NK1R-SNP rs881. Furthermore, DFS probabilities were calculated. RESULTS: Concerning the DFS preoperative pain levels and the NK1R genotype were independent predictors for a recurrence with hazard ratios of 2.55 (95% CI: 1.32-4.95) for patients with a high preoperative pain level and 0.44 for patients with a heterozygous or homozygous variant genotype in rs881 (95% CI: 0.21-0.88). CONCLUSION: The polymorphism rs811 seems to be associated with a lower recurrence risk in endometriosis patients. Thus, there might be a clinical relevant role of the NK1 pathway in the pain perception of endometriosis patients.

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Condition tags

endometriosisdysmenorrhea

MeSH descriptors

Endometriosis Endometriosis Genetic Predisposition to Disease Genetic Predisposition to Disease Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Receptors, Neurokinin-1 Adult Adult Case-Control Studies Case-Control Studies Disease-Free Survival Disease-Free Survival Endometriosis Endometriosis Endometriosis Female Female Genotype Genotype

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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