Neurokinin 1 receptor gene polymorphism might be correlated with recurrence rates in endometriosis

Stefan P Renner, Arif B Ekici, Christian Maihöfner, Peter Oppelt, Falk C Thiel, Michael Schrauder, Nesrin Uenluehan, Mayada R Bani, Pamela L Strissel, Reiner Strick, Matthias W Beckmann, Peter A Fasching
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2009 · vol. 25(11) , pp. 726–733 · doi:10.3109/09513590903159631 · PMID:19903051 · W2076661261
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This study found that the NK1R-SNP rs811 polymorphism was an independent predictor of disease-free survival, associating it with a lower recurrence risk in endometriosis patients.

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Abstract

INTRODUCTION: Dysmenorrhoea is the major symptom in women with endometriosis. Recently, pain modulation through Neurokinin-1-receptor (NK1R) pathways have been investigated in neuropathic pain patients. Aim of this study was, therefore, to examine the effect of a single nucleotide polymorphism (SNP) of the NK1R gene on the susceptibility for endometriosis and the disease free survival (DFS) after surgery for endometriosis. MATERIAL AND METHODS: A case-control study was conducted and germline DNA was isolated. Patients were followed up for a recurrence of the disease up to 4 years. Case-control analyses were performed for parameters of the medical history and the genotype of the NK1R-SNP rs881. Furthermore, DFS probabilities were calculated. RESULTS: Concerning the DFS preoperative pain levels and the NK1R genotype were independent predictors for a recurrence with hazard ratios of 2.55 (95% CI: 1.32-4.95) for patients with a high preoperative pain level and 0.44 for patients with a heterozygous or homozygous variant genotype in rs881 (95% CI: 0.21-0.88). CONCLUSION: The polymorphism rs811 seems to be associated with a lower recurrence risk in endometriosis patients. Thus, there might be a clinical relevant role of the NK1 pathway in the pain perception of endometriosis patients.

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Condition tags

endometriosisdysmenorrhea

MeSH descriptors

Endometriosis Endometriosis Genetic Predisposition to Disease Polymorphism, Single Nucleotide Receptors, Neurokinin-1 Adult Case-Control Studies Disease-Free Survival Endometriosis Endometriosis Female Genotype Heterozygote Homozygote Humans Kaplan-Meier Estimate Middle Aged Pain Pain Preoperative Period

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