Estrogen and progesterone receptors of the out-of-phase endometrium in female infertile patients

Hirama Y, Y Hirama, Yoshiaki Hirama, Kazunori Ochiai, K Ochiai, Ochiai K
Fertility and sterility · 1995 · vol. 63(5) , pp. 984–988 · doi:10.1016/s0015-0282(16)57534-7 · PMID:7720943 · W139839547
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This study investigated the expression of estrogen and progesterone receptors in the endometrium of infertile women experiencing an out-of-phase endometrial cycle.

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Abstract

ObjectiveTo examine the role of steroid hormone receptor compartmentalization in infertile women with "in-phase" or "out-of-phase" endometrium.DesignNonrandomized prospective clinical study.SettingA university clinic.PatientsTwenty-nine infertile patients without evidence of endometriosis, tubal factor, male factor, galactorrhea, or hyperandrogenism were enrolled. Sixteen patients had in-phase endometrium and a P level > or = 10 ng/mL (conversion factor to SI unit, 3.18) (group A). Four patients had out-of-phase endometrium and a P level > 10 ng/mL (group B). Four patients had in-phase endometrium and a P level < 10 ng/mL (group C), and five patients had out-of-phase endometrium and a P level < 10 ng/mL (group D).Main outcome measuresEach patient underwent determination of serum P and endometrial sampling on postovulatory days 6 to 9 based on serum LH measurement. Dating according to endometrial histology and biochemical assessment of estrogen receptor (ER) and P receptor (PR) were performed on each sample.ResultsThe level of cytosol ER was significantly lower in out-of-phase endometrium regardless of serum P level. There were no significant differences in the levels of cytosol PR and nuclear ER and PR among groups. In a long-term follow-up study, 6 of 29 patients became pregnant. The cytosol ER:PR ratio in these patients was found to fit a single straight regression line (y = 0.34x - 2.2).ConclusionOut-of-phase endometrium probably depends on inadequate cytosol ER. An appropriate cytosol ER:PR ratio may be important to become pregnant.

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MeSH descriptors

Endometrium Infertility, Female Receptors, Estrogen Receptors, Progesterone Adult Cell Nucleus Cell Nucleus Cytosol Cytosol Endometrium Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Infertility, Female Luteal Phase Luteal Phase Luteinizing Hormone

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References (19)

Cited by (9)

SciLite annotations

chemicals 1
estrogen

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