Pseudocorpus Luteum Insufficiency: A Local Defect of Progesterone Action on Endometrial Stroma

David W. Keller, Walter G. Wiest, Frederic B. Askin, Larry Johnson, R.C. Strickler
In: The Journal of Clinical Endocrinology & Metabolism · 1979 · vol. 48(1) , pp. 127–132 · doi:10.1210/jcem-48-1-127 · PMID:217888 · W2053748157
article OA: closed CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-14 ⓘ

This study reports a case of infertility due to an abnormal endometrial stromal response to progesterone, possibly caused by reduced progesterone receptor numbers or resistance in the target tissue.

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Abstract

A 23-yr-old woman whose initial complaint was infertility demonstrated glandular stromal dissociation with failure of the endometrial stroma to undergo pseudodecidualization in repeated endometrial biopsies taken late in the luteal phase. As the clinical presentation was consistent with the inadequate corpus luteum syndrome, hormone measurements were performed. The endometrial biopsy was abnormal during cycles in which the serum pattern of progesterone, estradiol, FSH, and LH was normal. Exogenous progesterone did not correct the abnormality. The patient, by in vitro studies, has approximately one half the number of high affinity progesterone-binding sites in the cytosol fraction of her endometrium compared to preparations from two normal control subjects. Since her cytosol-binding protein was qualitatively identical to two control subjects, the incomplete maturation of her endometrial stroma may represent an absence or reduced number of stromal cytosol receptors and/or a resistance to specific hormone action in an individual target tissue.

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infertility

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