Estrogen receptor, progesterone receptor and CD8+ expression in endometrium of women of unexplained infertility

Shilpi Gupta Dixit, Surajit Ghatak, Pratibha Singh, Shilajit Bhattacharya
In: Journal of Gynecology Obstetrics and Human Reproduction · 2018 · vol. 47(10) , pp. 533–537 · doi:10.1016/j.jogoh.2018.05.006 · PMID:29783035 · W2804433359
article OA: closed CC0 ⤵ 2 in-corpus citations
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This study investigated the expression levels of estrogen receptor, progesterone receptor, and CD8+ T cells in the endometrium of women experiencing unexplained infertility.

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Abstract

ObjectiveThe present study aimed to investigate the changes of endometrial progesterone and estrogen receptors in luteal phase biopsy specimens of infertile women and find a correlation, if any, between these and CD8+ receptors in the same.MethodsThe study was conducted on luteal phase endometrial biopsy specimens of 30 women of unexplained infertility and 15 age matched controls. Paraffin sections were first H & E stained. A standardized immunohistochemical protocol was then used to localize the estrogen, progesterone and CD8+ receptors in these samples that were expressed as percentage positivity. Unpaired T test was applied between the controls and cases both for epithelial and stromal cells. The data was also analyzed for correlation in cases for the positivity of CD8+ Cells with that of ER and PR.ResultsThe positivity of estrogen receptors (ER) in stromal cells was significantly lower (p<0.001) in the infertile women when compared to controls and in both the epithelial and stromal cells for progesterone receptors (p<0.001). The results were non significant for CD8+ cells (p=0.19) and also showed no significant correlation in the positivity of CD8+ cells with that of ER and PR.ConclusionsThe development of molecular probe like ER and PR positivity in endometrial epithelial and stromal cells allows a new approach to be made to the characterization of normal and defective endometrial function.

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