Estrogen receptor, progesterone receptor and CD8+ expression in endometrium of women of unexplained infertility

Shilpi Gupta Dixit, Surajit Ghatak, Pratibha Singh, Shilajit Bhattacharya
Journal of gynecology obstetrics and human reproduction · 2018 · vol. 47(10) , pp. 533–537 · doi:10.1016/j.jogoh.2018.05.006 · PMID:29783035 · W2804433359
Observational OA: closed CC0 ⤵ 2 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated the expression levels of estrogen receptor, progesterone receptor, and CD8+ T cells in the endometrium of women experiencing unexplained infertility.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: The present study aimed to investigate the changes of endometrial progesterone and estrogen receptors in luteal phase biopsy specimens of infertile women and find a correlation, if any, between these and CD8+ receptors in the same. METHODS: The study was conducted on luteal phase endometrial biopsy specimens of 30 women of unexplained infertility and 15 age matched controls. Paraffin sections were first H & E stained. A standardized immunohistochemical protocol was then used to localize the estrogen, progesterone and CD8+ receptors in these samples that were expressed as percentage positivity. Unpaired T test was applied between the controls and cases both for epithelial and stromal cells. The data was also analyzed for correlation in cases for the positivity of CD8+ Cells with that of ER and PR. RESULTS: The positivity of estrogen receptors (ER) in stromal cells was significantly lower (p<0.001) in the infertile women when compared to controls and in both the epithelial and stromal cells for progesterone receptors (p<0.001). The results were non significant for CD8+ cells (p=0.19) and also showed no significant correlation in the positivity of CD8+ cells with that of ER and PR. CONCLUSIONS: The development of molecular probe like ER and PR positivity in endometrial epithelial and stromal cells allows a new approach to be made to the characterization of normal and defective endometrial function.

My notes (saved in your browser only)

Condition tags

infertility

MeSH descriptors

Corneal Stroma Endometrium Epithelium Infertility, Female Receptors, Antigen, T-Cell Receptors, Estrogen Receptors, Progesterone Adult Biopsy Corneal Stroma Endometrium Epithelium Female Humans Immunohistochemistry Infertility, Female Luteal Phase Receptors, Antigen, T-Cell Receptors, Estrogen Receptors, Progesterone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (23)

Cited by (2)

Source provenance

openalex
last seen: 2026-05-11T06:38:17.545654+00:00
pubmed
last seen: 2026-10-08T21:22:05.765370+00:00
License: CC0 · commercial use OK